Die Verteilung von J131-Albumin in der Niere von Ratten und Kaninchen

Summary The renal uptake and intrarenal distribution of J¹³¹-Albumin has been studied after i.v. injection in rats and rabbits by counting and frozen section radioautography. In kidney cortex radioalbumin is distributed not only intravasally and interstitially but also located intracellularly to a significant degree. Concepts based on the assumption of exclusive extracellular distribution of albumin-such bumin-such as concerning the intrarenal hematocrit or the significance of the interstitial cortical albumin-therefore might need reevaluation. In contrast to renal cortex papilla and outer medulla vascular zones showed only extracellular radioalbumin distribution with probably high concentrations in the interstitial compartment. Radioalbumin distribution kinetics in the various regions of the kidney were different; this difference might lead to errors concerning the endogenous albumin-pool, if conclusions are based without differentiation on total renal activity only.

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