急性脊髓损伤患者血清中单核趋化蛋白-1的表达及其意义

目的 :观察急性不完全脊髓损伤患者血清中单核细胞趋化蛋白 1(MCP 1)的表达 ,探讨继发性脊髓损伤的可能机制。方法 :收集 2 8例急性不完全脊髓损伤患者、8例单纯脊柱压缩骨折患者及正常对照的血清 ,ELISA方法检测其中MCP 1的水平 ,并分析其入院时的MRI资料。结果 :与健康对照相比 ,急性不完全脊髓损伤患者血清中MCP 1的浓度明显增高 (P <0 0 1) ;且水平与脊髓受压程度及脊髓损伤的病理类型有相关性 (P <0 0 5 )。结论 :MCP 1可能参与脊髓损伤部位的继发性炎症反应 ,其血清浓度与诊断、预后有一定关系。

The expression and its significance of MCP-1 in the serum of patients with acute spinal cord injury

Objective:To measure the expression of the MCP-1(Monocyte Chemoattractant Protein-1) in the serum of patients with acute spinal cord injury and explore the possible mechanism of secondary spinal cord injury.Methods:MCP-1 in the serum of patients with acute spinal cord injury,single spine compression and healthy subjects were detected by ELISA irrespectively.The MRI data of these patients were studied at the same time on a blind base.Results:MCP-1 in the serum of patients with acute spinal cord injury was correlated positively with the degree of spinal cord compression,which was elevated markedly(P<0.01) compared with the controls,and was related with the pathologic classification of the spinal cord injury.Conclusion:MCP-1 may induce secondary inflammatory response by recruiting inflammatory cells to the injury site and thus affect the prognosis of spinal cord injury.