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雷公藤甲素对兔血管平滑肌细胞增生和凋亡的影响
引用本文:游方. 雷公藤甲素对兔血管平滑肌细胞增生和凋亡的影响[J]. 中国当代医药, 2009, 16(23): 16-17
作者姓名:游方
作者单位:福建医科大学附属协和医院急诊内科,福建,福州,350001
摘    要:目的:研究雷公藤甲素(TP)是否具有抑制血管平滑肌细胞(VSMCs)增殖并诱导其发生凋亡的作用,为临床开发新型药物洗脱支架提供实验依据。方法:体外主动脉SMCs培养和流式细胞仪检测,DNA凝胶电泳。结果:TP组与空白对照组及地塞米松组相比,凋亡率有显著提高;TP干预组凝胶电泳谱型呈凋亡特征性梯状条带。结论:TP可抑制指数生长期SMCs增殖并诱导其凋亡。

关 键 词:雷公藤甲素  血管平滑肌细胞  细胞凋亡

Effect of Triptolide on rabbit vascular smooth muscle cell proliferation and apoptosis
YOU Fang. Effect of Triptolide on rabbit vascular smooth muscle cell proliferation and apoptosis[J]. http://www.botanicus.org/, 2009, 16(23): 16-17
Authors:YOU Fang
Affiliation:YOU Fang (Emergency Medicine of Affiliatcd Union Hospital of Fujian Medical University Fuzhou 350001,China)
Abstract:Objective:To study whether or not the Triptolide could inhibit vascular smooth muscle cells proliferation and induce apoptosis,and provided experimental basis of the role of the clinical development of novel drug-eluting stents. Methods:The cells were primary SMCs culture and flow cytometry, DNA gel electrophoresis. Results:TP group compared with dexarnethasone and positive control, apoptosis rate significantly inereased;TP group gel eleetrophoresis profiles of the intervention group showed the characteristic apoptotie DNA ladder. Conclusion:TP inhibit the exponential phase of growth and induce apoptosis of SMCs proliferation.
Keywords:Triptolide  Vascular smooth muscle ceils  Apoptosis
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