| The Effects of Extracellular Matrix on Tissue Engineering Construction of Cartilage in Vitro |
| |
| 作者姓名： | YU Li~ LI Fa-tao ~ TANG Ming-qiao~ YAN Wei-qun~ . |
| |
| 作者单位： | YU Li~ 1，LI Fa-tao ~1，TANG Ming-qiao~2，YAN Wei-qun~2 1.Department of Biochemistry of Medical College，Jinan University，Guangzhou 510632，China2. Institute of Applied Mechanics of Jinan University，Guangzhou 510632，China3. Jilin University，Changchun 130021，China |
| |
| 基金项目： | 教育部科学技术研究项目;广东省广州市自然科学基金 |
| |
| 摘 要： | In the study of bone and cartilage diseases in our laboratory, chondrocyte stereo-differentiation mod-el was cultured into cartilage tissue. The cultured cartilage tissue was closely similar to natural tissue inboth histological condition and biochemical metabolism. The model mimicked the chondrocyte differenti-ation and metabolism in vivo completely〔1〕. We studied some essential extracellular matrices, includingcollagen, proteoglycan(PG) and hyaluronic acid(HA) on the construction of grow…
|
The Effects of Extracellular Matrix on Tissue Engineering Construction of Cartilage in Vitro |
| |
| YU Li ,LI Fa-tao ,TANG Ming-qiao,YAN Wei-qun ..The Effects of Extracellular Matrix on Tissue Engineering Construction of Cartilage in Vitro[J].Chinese Journal of Biomedical Engineering,2006,15(2). |
| |
| Authors: | YU Li LI Fa-tao TANG Ming-qiao YAN Wei-qun |
| |
| Institution: | 1. Department of Biochemistry of Medical College,Jinan University,Guangzhou 510632,China
2. Institute of Applied Mechanics of Jinan University,Guangzhou 510632,China |
| |
| Abstract: | The effects of various cartilage extracellular matrix on the construction of rabbit growth plate cartilage tissue in vitro were studied. The results show that collagen, proteoglycan and hyaluronic acid can promote the growth of cultured chondrocytes but the effects of various cartilage extracellular matrix(ECM)on chondrocyte differentiation are different. Collagen can promote the hypertrophy of chondrocytes while proteoglycan and hyaluronic acid inhibit the transition of mature chondrocytes into hypertrophied chondrocytes. |
| |
| Keywords: | Extracellular matrix Tissue engineering cartilage Chondrocyte |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
