影响近视眼角膜中央厚度的多因素探讨

目的:探讨影响近视眼患者角膜中央厚度的相关因素。方法:用超声角膜测厚仪检测630例(1260眼)近视及近视散光眼患者的中央角膜厚度,统计分析检测结果。结果:角膜中央厚度与眼内压呈正相关(r=0.416,P=0.01)。角膜中央厚度大约每增加28.8μm,眼内压上升1mmHg,角膜中央厚度与屈光度呈负相关(r=0.426,P<0.05)。角膜中央厚度与是否戴角膜接触镜有关,长期持续配戴软性角膜接触镜者平均中央角膜厚度为530.26±32.73μm,无角膜接触镜配戴史者平均中央角膜厚度为545.89±29.71μm,二者比较差异有显著性(P<0.05);散瞳前角膜中央厚度为532.77±32.21μm,散瞳后角膜中央厚度为539.97±31.31μm,二者比较差异有显著性(P=0.001)。结论:近视角膜中央厚度除与眼内压、屈光度及是否配戴软性角膜接触镜等因素有关,散瞳剂也是影响角膜中央厚度的因素之一。

Factors correlated to central thickness in patients with myopia

AIM: To investigate the factors correlated to central corneal thickness (CCT) in patients with myopia. ·METHODS: A total of 630 cases (1260 eyes) with myopia or myopia astigmatism were enrolled in this study. Packet-Ⅱ ultrasound pachymetry were used to detect CCT of each eye. The results were recorded and analyzed. ·RESULTS: The correlation between non-contact tonometry (NCT) and CCT was positive (r=0.416, P=0.01 ), an approximate increase of 1mmHg for an increase in CCT of 28.8μm, A negative correlation was found between CCT and refraction (r=0.426, P<0.05 ). The mean CCT was 530.26±32.73μm and 545.77±32.21μm in long-terms of contact lens wear and normal eyes, respectively(t=-6.15, P=0.01). The mean CCT was 532.77±32.21μm before mydriasis and 539.97±31.31μm after mydriasis with significant difference (t=-9.67, P=0.001). ·CONCLUSION: The CCT is related to intraocular presure, refraction, long-term sofe contact lens and mydriasis.