小花五味子中抗HIV活性的木脂素类化合物

目的：从小花五味子中发现具有抗HW活性的化学成分。方法：采用多种柱层析分离进行化合物的分离和纯化．通过波谱分析鉴定化合物的结构，化合物的抗HIV-1活性通过对HIV-1感染C8166细胞致细胞病变的抑制试验得到。结果：从小花五味子的茎藤部分分离得到了4个木脂素，分别鉴定为micrantherin A(1)，gomisin K3(2)，gomisin G(3)和vladinol F(4)。化舍物4具有显著的抗HIV-1活性，IC50=3.51μg／mL，选择指数为27、45。结论：化合物1为新的木脂素，化合物4的抗HIV-1活性值得进一步研究。

Anti-HIV Lignans from Schisandra micrantha

AIM: To find new natural compounds with anti-HIV activity from Schisandra micrantha. METHORD: The chemical constituents of Schisandra micrantha were isolated by various column chromatographic methods. Their structures were assigned by spectroscopic methods including 2D NMR experiments, and their anti-HIV-1 activities and cytotoxicities were tested by microtiter syncytium formation infectivity assay. RESULT: Four lignans, micrantherin A (1), gomisin K3 (2), gomisin G (3), and vladinol F (4) were isolated from the leaves and stems of Schisandra micrantha. Vladinol F (4) was found to show potent anti-HIV-1 activity with IC50 value of 3.51 μg/mL and a selective index of 27.45. CONCLUSION: Micrantherin A (1) was a new lignan.