| TNHH对大鼠全脑缺血再灌注损伤的抗氧化性保护作用 |
| |
| 引用本文： | 于晓彦,魏欣冰,陈琳,张岫美. TNHH对大鼠全脑缺血再灌注损伤的抗氧化性保护作用[J]. 中国生化药物杂志, 2009, 30(1) |
| |
| 作者姓名： | 于晓彦 魏欣冰 陈琳 张岫美 |
| |
| 作者单位： | 山东大学,医学院,药理学研究所,山东,济南,250012 |
| |
| 摘 要： | 目的观察TNHH对大鼠全脑缺血再灌注损伤的抗氧化性保护作用。方法以改良的四血管阻塞法(Pulsinelli four-vessel occlusion model)建立大鼠全脑缺血模型,于缺血30 min,再灌注48 h后进行脑组织超氧化物歧化酶(SOD)、丙二醛(MDA)、髓过氧化物酶(MPO)测定。结果TNHH能显著降低大鼠缺血损伤脑组织中MDA含量,降低MPO活性,提高SOD活性。结论TNHH对大鼠全脑缺血再灌注损伤的具有明显的抗氧化作用。
|
| 关 键 词： | 脑缺血再灌注损伤 TNHH 抗氧化 |
Antioxidant effects of TNHH on whole brain ischemia/reperfusion injury in rats |
| |
| YU Xiao-yan,WEI Xin-bing,CHEN Lin,ZHANG Xiu-mei. Antioxidant effects of TNHH on whole brain ischemia/reperfusion injury in rats[J]. Chinese Journal of Biochemical Pharmaceutics, 2009, 30(1) |
| |
| Authors: | YU Xiao-yan WEI Xin-bing CHEN Lin ZHANG Xiu-mei |
| |
| Affiliation: | Department of Pharmacology;School of Medicine;Shandong University;Jinan 250012;China |
| |
| Abstract: | Purpose To investigate the antioxidant effects of TNHH on global cerebral ischemia reperfusion injury in rats.Methods Modified Pulsinelli four-vessel occlusion model in rat was prepared to produce the cerebral ischemia reperfusion injury.After ischemia for 30 min and reperfusion for 48 h,superoxide dismutase(SOD)activity,malondialdehyde(MDA)level,and myeloperoxidase(MPO)activity in brain tissue were measured.Results TNHH produced significant reductions in MDA content,MPO activity and elevation in SOD activi... |
| |
| Keywords: | TNHH |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
