一氧化氮在肿瘤生长转移中的作用

目的 探讨一氧化氮(NO)在肿瘤生长、转移中的作用。方法 对近年来有关文献加以综述。结果 NO在肿瘤生长转移中具有双重作用，一方面NO通过干扰肿瘤细胞代谢，引起DNA损伤，形成高毒性的羟自由基，诱导肿瘤细胞凋亡，介导巨噬细胞和内皮细胞的杀瘤作用，发挥其抗肿瘤的作用；另一方面NO通过调节细胞增殖相关基因的表达，可诱导肿瘤血管形成，而具有促肿瘤生长作用。结论 选择性阻断或诱导NO的合成，使其发挥抗肿瘤作用，将为肿瘤的治疗提供新的思路和方法。

Effects of Nitric Oxide on Growth and Metastasis of Tumor

Objective To study the effects of nitric oxide (NO) on the growth and metastasis of tumor.Methods The literatures of recent years were reviewed.Results NO had double effects on the growth and metastasis of tumor. NO promoted the growth and metastasis by regulating the expression of tumor proliferation gene and inducing tumor angiogenesis. On the other hand, NO had antitumor effects by interfering with the metabolism of tumor cells, inducing the damage of DNA, forming high toxic free radical, inducing apoptosis of tumor cells and mediating the antitumor action of endothelial cells and macrophages.Conclusion Selective blockage or induction of synthesis of NO may be a new way for tumor therapy.