口服亚硒酸钠预防克山病发病的研究

<正> 自1957年Schwarz报告硒能防止大白鼠的急性肝坏死以及1973年Rotruck等发现硒是谷胱甘肽过氧化物酶的重要组成部份后,硒的生物化学功能的研究得到迅速发展。虽然从动物得到的材料表明硒很可能是一种必需微量元素,但尚缺乏硒与人体健康或疾病有关的直接证据。

OBSERVATIONS ON THE EFFECT OF SODIUM SELENITE IN THE PREVENTION OF KESHAN DISEASE

To evaluate the efficacy of sodium selenite in the prevention of Ke-shan disease, a study was carried out among children in Mianning county, Sichuan province, from 1974 to 1977 inclusive. The morbidity of Keshan disease in selenium (Se) supplemented children was found to be 2.2‰. and 1.0‰ in 1974 and 1975 respectively while that in the control groups was 13.5‰ and 9.5‰, the differences being highly significant in both years. In 1976, both groups were given sodium selenite and the incidence rate was further decreased to 0.32‰. In 1977, no new case of this disease was discovered among the treated children.Of the 17 cases occurred in the Se supplemented group during 1974 and 1975, only one died at the end of 1977, while of the 106 cases occurred in the control group during the same time, 53 became fatal. These results indicated that sodium selenite could not only lower the morbidity of Keshan disease but also improve prognosis.The possible mechanisms of sodium selenite in the prevention of Keshan disease were discussed.