| 造血干细胞移植治疗儿童血液肿瘤及难治性血液病53例临床观察 |
| |
| 引用本文： | 向茜茜,孔佩艳,赵艳,曾东风,刘红,陈幸华,张曦,李杰平,彭贤贵,高蕾,高力.造血干细胞移植治疗儿童血液肿瘤及难治性血液病53例临床观察[J].第三军医大学学报,2010,32(20). |
| |
| 作者姓名： | 向茜茜 孔佩艳 赵艳 曾东风 刘红 陈幸华 张曦 李杰平 彭贤贵 高蕾 高力 |
| |
| 作者单位： | 第三军医大学新桥医院血液科,重庆,400037 |
| |
| 基金项目： | 重庆市重点学科建设基金(CSTC2009BA5011)~~ |
| |
| 摘 要： | 目的观察造血干细胞移植治疗儿童血液肿瘤及其他难治性血液病的临床疗效。方法自2007年4月至2009年12月,我们共对53例血液病患儿实施了造血干细胞移植治疗,其中自体移植15例,异基因移植38例,观察其临床疗效和并发症。结果 15例患者行自体外周血造血干细胞移植后造血功能均能顺利重建,无严重并发症发生。异基因移植患儿除1例发生颅内出血早期死亡外,其余均顺利达到造血重建,但其中急性移植物抗宿主病发生率为18.4%,慢性移植物抗宿主病发生率2.6%;15例患儿于移植后0～24个月分别死于颅内出血、感染和疾病复发或进展;移植后6个月至2年存活率65%。结论造血干细胞移植是治疗儿童血液肿瘤及其他难治性血液病的有效方法,可明显改善预后;临床可根据患者原发疾病诊断、供者情况及家庭经济条件选择移植方式。
|
| 关 键 词： | 儿童血液病 造血干细胞移植 自体 异基因 |
Hematopoietic stem cell transplantation for children's hematologic malignancies and refractory hematological diseases:report of 53 cases |
| |
| Xiang Xixi,Kong Peiyan,Zhao Yan,Zeng Dongfeng,Liu Hong,Chen Xinghua,Zhang Xi,Li Jieping,Peng Xiangui,Gao Lei,Gao Li.Hematopoietic stem cell transplantation for children's hematologic malignancies and refractory hematological diseases:report of 53 cases[J].Acta Academiae Medicinae Militaris Tertiae,2010,32(20). |
| |
| Authors: | Xiang Xixi Kong Peiyan Zhao Yan Zeng Dongfeng Liu Hong Chen Xinghua Zhang Xi Li Jieping Peng Xiangui Gao Lei Gao Li |
| |
| Institution: | Xiang Xixi,Kong Peiyan,Zhao Yan,Zeng Dongfeng,Liu Hong,Chen Xinghua,Zhang Xi,Li Jieping,Peng Xiangui,Gao Lei,Gao Li(Department of Hematology,Xingqiao Hospital,Third Military Medical University,Chongqing,400037,China) |
| |
| Abstract: | Objective To evaluate the therapeutic effect of hematopoietic stem cell transplantation for children's hematologic malignancies and refractory hematological diseases.MethodsA total of 53 children with hematologic malignancies and refractory hematological diseases were subjected in hematopoietic stem cell transplantation(allogenetic in 38 patients,autologous in 15 patients)from April 2007 to December 2009.There were 14 cases of acute myeloid leukemia(AML),12 cases of acute lymphoblastic leukemia(ALL),3 cases... |
| |
| Keywords: | children's refractory hematologic diseases children's hematologic malignancies hematopoietic stem cell transplantation autologous allogenetic |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
