比亚芬预防放射性皮肤损伤的疗效观察

目的　观察比亚芬乳膏预防急性放射性皮肤损伤的临床疗效。方法　将 10 4例需要放射治疗的患者随机分为 2个组 ,5 6例在第 1次放射治疗后给予比亚芬涂抹为用药组 ,4 8例只做常规放射治疗宣教和健康教育为对照组。结果　皮肤反应发生率对照组和用药组分别为 93.8%、30 .4 %。轻度放射反应 ( 1 2级 )对照组为 6 6 .7% ( 32 / 4 8) ,用药组为 2 8.6 % ( 16 / 5 6 )。皮肤反应发生剂量对照组 91.1% ( 4 1/ 4 5 )出现于照射 4 0Gy以前 ,用药组为 2 9.4 % ( 5 / 17)。结论　比亚芬能有效地预防放射性皮炎的发生 ,对患者能减轻痛苦、提高生活质量、保证放射治疗的顺利进行

Clinical effect of biafine cream to prevent irradiation-induced dermal injury

Objective To observe the clinical effect of Biafine cream to prevent acute irradiation-induced dermal injury. Methods 104 patients who had to accept radiotherapy were randomized into two groups:treatment group(56 cases) was give Biafine cream application since the first radiotherapy session while the other 48 served as control without this medication when general and health education program was given. Results Dermal toxic rate and degree in the treatment group were obviously lower than those of the control group, with the difference between the two groups significant. Conclusions Biafine cream can effectively prevent acute irradiation-induced dermal injury. It can alleviate the patients' suffering and improve their quality of life, so as to ensure uneventful radiotherapy .