B型脑利钠肽及N端脑利钠肽前体与舒张性心力衰竭的诊断

心力衰竭患者中舒张性心力衰竭占相当大的比例,其预后与收缩性心力衰竭相似,而目前对于舒张性心力衰竭的诊断尚缺乏简便客观的手段及统一的标准,尤其早期诊断更加困难,以致漏诊率、误诊率较高。B型脑利钠肽及N端脑利钠肽前体作为充血性心力衰竭的客观生化指标,其对舒张性心力衰竭的诊断价值也为一系列临床研究所证实,虽然尚存在争议,但相信在将来随着研究的深入,B型脑利钠肽及N端脑利钠肽前体可能会成为早期诊断舒张性心力衰竭的可靠的生化指标之一,并且可能有明确的分界值,从而使舒张性心力衰竭诊断变得简便易行、客观可靠。

BNP/NT-proBNP and Diagnosis of Diastolic Heart Failure

Diastolic heart failure accounts fur a high proportion of patients suffering from congestive heart failure. However, because of the lack of simple, objective methods and a unified standard for the diagnosis of diastolic heart failure, especially its early diagnosis, the rate of omission and misdiagnosis is quite high. B type natriuretic peptide and N-terminal proBNP are two objective biochemical indexes in con- gestive heart failure. Their diagnostic values in diastolic heart failure have been proven clinical research. Although there is controversy among scholars over their diagnostic value, we believe that with further development in research, BNP and NT-proBNP may become one of the relia- ble biochemical indexes respectively in the early diagnosis of diastolic heart failure. Moreover, they may have clear boundary values in the field in future, and possibly making the diagnosis of diastolic heart failure simple, accurate and reliable.