| CBTX-A治疗痉挛性脑性瘫痪临床研究 |
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| 引用本文： | 高宝勤,杨伟力,王雅洁,田朝霞,邓亚仙. CBTX-A治疗痉挛性脑性瘫痪临床研究[J]. 中华神经医学杂志, 2005, 4(5): 488-490 |
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| 作者姓名： | 高宝勤 杨伟力 王雅洁 田朝霞 邓亚仙 |
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| 作者单位： | 100050,首都医科大学附属北京天坛医院儿科 |
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| 摘 要： | 目的研究国产A型肉毒毒素(CBTX-A)局部注射治疗小儿痉挛性脑瘫的疗效,副作用。方法选择1000例痉挛性小儿脑性瘫痪患儿,以每组肌肉2.5U/kg用量进行痉挛肌肉局部注射。应用PRS(physicianratingscale)法比较治疗前及治疗后1个月时运动姿势的改善情况。观察治疗中及治疗后的副作用。结果绝大多数患儿治疗后其PRS疗效指标均有不同程度的改善,其有效率为99.7%,P<0.01。除5例(0.5%)注射后短期内患肢无力外,其他均无明显副作用发生。结论CBTX-A局部注射是一种安全、有效、方便灵活、较少副作用的治疗小儿痉挛性脑瘫的好方法。
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| 关 键 词： | A性肉毒毒素 脑性瘫痪 治疗 |
| 文章编号： | 1671-8925(2005)05-488-003 |
| 修稿时间： | 2005-03-18 |
Injection of CBTX-A in the treatment of spastic cerebral palsy |
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| GAO Bao-qin,YANG Wei-li,WANG Ya-jie,TIAN Chao-xia,DENG Ya-xian. Injection of CBTX-A in the treatment of spastic cerebral palsy[J]. Chinese Journal of Neuromedicine, 2005, 4(5): 488-490 |
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| Authors: | GAO Bao-qin YANG Wei-li WANG Ya-jie TIAN Chao-xia DENG Ya-xian |
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| Abstract: | Objective To evaluate the efficacy and side effects of local in tramuscular injection of Chinese botulinum toxin type A (CBTX-A) in the treatmen t of spastic cerebral palsy. Methods 1000 children with spastic cerebral palsy were treated with CBTX-A (2.5 U/kg). The therapeutic efficacy was evaluate d by physician rating scale (PRS) and the improvement index of movement and post ure before and 1 month after the treatment was calculated. The tolerance to CBTX -A and the side effects were also assessed. Results The movement and postu re was improved in 99.7% children treated with CBTX-A (P<0.01). No obvious side effects were found but weakness in injured limb in the short term after injectio n. Conclusion CBTX-A proves a simple, safe and effective method in the trea tment of the cerebral palsy. |
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| Keywords: | Botulinum toxin type A Cerebral palsy Therapy |
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