| 动物类中药中蛋白多肽成分的口服吸收机制及其研究进展 |
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| 引用本文： | 何忠梅,李超华,孙娅楠,赵静,王毅.动物类中药中蛋白多肽成分的口服吸收机制及其研究进展[J].上海中医药杂志,2016,50(9):97-100. |
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| 作者姓名： | 何忠梅 李超华 孙娅楠 赵静 王毅 |
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| 作者单位： | 吉林农业大学中药材学院,吉林长春,130118,吉林农业大学中药材学院,吉林长春,130118;北京市中医药防治重大疾病基础研究重点实验室,中国中医科学院医学实验中心,北京,100700,北京市中医药防治重大疾病基础研究重点实验室,中国中医科学院医学实验中心,北京,100700,吉林农业大学中药材学院,吉林长春,130118,北京市中医药防治重大疾病基础研究重点实验室,中国中医科学院医学实验中心,北京,100700 |
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| 基金项目： | 国家自然科学基金项目(81373884)；中央级公益性科研院所基本科研业务费专项基金资助项目(ZZ2013005,ZZ0808011)；吉林省科技发展计划项目(20140311029YY) |
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| 摘 要： | 综述动物类中药中蛋白多肽成分的口服吸收机制及其研究进展。通过查阅国内外文献总结蛋白多肽类物质主要是通过载体转运、胞饮作用和M细胞途径、细胞旁路、谷胱甘肽(GSH)转运系统这4种方式进行吸收转运,并分析了临床疗效显著的蛇毒、水蛭素、蚓激酶、鹿茸这4种动物类来源蛋白口服吸收入血途经及部分相关机制,对开发口服动物来源蛋白多肽类药物具有极大的应用价值和推广意义。
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| 关 键 词： | 动物类中药 蛋白多肽 吸收机制 口服给药 综述 |
| 收稿时间： | 2015/11/15 0:00:00 |
Advances in mechanism research on the oral absorption of protein polypeptide components in Chinese traditional medicine from animal |
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| HE Zhong-mei,LI Chao-hu,SUN Ya-nan,ZHANG Jing and WANG Yi.Advances in mechanism research on the oral absorption of protein polypeptide components in Chinese traditional medicine from animal[J].Shanghai Journal of Traditional Chinese Medicine,2016,50(9):97-100. |
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| Authors: | HE Zhong-mei LI Chao-hu SUN Ya-nan ZHANG Jing and WANG Yi |
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| Institution: | College of Chinese Medicine Materials,Jilin Agricultural University,Changchun,130118,College of Chinese Medicine Materials,Jilin Agricultural University,Changchun,130118;Beijing Key Laboratory of TCM Basic Research on Prevention and Treatment of Major Disease, Experimental Research Center,China Academy of Chinese Medical Science,Beijing,100700,Beijing Key Laboratory of TCM Basic Research on Prevention and Treatment of Major Disease, Experimental Research Center,China Academy of Chinese Medical Science,Beijing,100700,College of Chinese Medicine Materials,Jilin Agricultural University,Changchun,130118 and Beijing Key Laboratory of TCM Basic Research on Prevention and Treatment of Major Disease, Experimental Research Center,China Academy of Chinese Medical Science,Beijing,100700 |
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| Abstract: | This article reviewed the mechanism research progress on the oral absorption of protein polypeptide components in Chinese traditional medicine from animal. By consulting and summarizing the domestic and foreign literature, it suggested that the absorption and transportion of protein peptides were mainly performed through the carrier transport, pinocytosis and M cell pathway, cell bypass and glutathione (GSH) transport system.Meanwhile the process of oral absorption into the blood and relevant mechanisms of venom, hirudin, lumbrokinase, pilose antler,4 kinds of protein from animal source with significant clinical effect were analyzed,which showed great application value and significance for the development of protein polypeptide drugs from animal source. |
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| Keywords: | Chinese traditional medicine from animal protein polypeptide absorption mechanism oral administration review |
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