口腔基底样鳞状细胞癌的临床病理及免疫组织化学特点

目的研究口腔基底样鳞状细胞癌的临床病理学特点。方法用ＨＥ染色、病理学观察及免疫组织化学染色法对１４例基底样鳞状细胞癌进行了分析。结果口腔基底样鳞状细胞癌占口腔鳞状细胞癌的１％，男性多于女性，可发生在口腔粘膜任何部位，临床表现主要为肿物和溃疡。肿瘤由基底样细胞和鳞状细胞构成，以基底样细胞为主，常形成粉刺样坏死，核分裂较多，邻近上皮常有异常增生。肿瘤细胞角蛋白ＡＥ１／３、ＣＫ１３阳性，Ｓ１００阴性，增殖细胞核抗原（ｐｒｏｌｉｆｅｒａｔｉｎｇｃｅｌｎｕｃｌｅａｒａｎｔｉｇｅｎ，ＰＣＮＡ）阳性细胞多，ｐ５３阳性率为５０％。３５．７％的病例初次手术时已有淋巴结转移。结论口腔基底样鳞状细胞癌较普通鳞状细胞癌恶性程度高，具有独特的组织学特点，临床及病理上应予重视。

Basaloid squamous cell carcinoma: clinical pathological and immunohistochemical study]

OBJECTIVE: To investigate the clinicopathological and immunohistochemical characteristics of basaloid squamous cell carcinoma of oral cavity. METHODS: Routine HE staining and immunohistochemical staining. RESULTS: Basaloid squamous cell carcinoma accounted for 1% of oral squamous cell carcinoma and was more common in male. It could be found at anysite of oral mucosa. The tumor was composed of basaloid cells and squamous cells. Basaloid cell, the main tumor cell, arranged in sheets and nests. Mitosis and comedoform necrosis was often seen. Adjacent oral epithelium often exhibited dysplasia. The tumor cells were cytokeratin positive, S-100 negative; PCNA index was high; 50% cases were p53 positive. CONCLUSION: Oral basaloid squamous cell carcinoma was a higher grade malignant tumor as compared with usual squamous cell carcinoma and should be paid great attention both in treatment and in pathological diagnosis.