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| 细胞周期蛋白E在胃癌中的表达及其与细胞增殖活性的关系 | |
| 引用本文： | 夏加增,王心南,杨继昌,尹浩然,朱正钢. 细胞周期蛋白E在胃癌中的表达及其与细胞增殖活性的关系[J]. 实用临床医药杂志, 1999, 0(2) |
| 作者姓名： | 夏加增 王心南 杨继昌 尹浩然 朱正钢 |
| 作者单位： | 无锡市第二人民医院!无锡，214002上海第二医科大学瑞金医院外科博士研究生，无锡市第二人民医院!无锡，214002，无锡市第二人民医院!无锡，214002，上海第二医科大学瑞金医院!上海，200000，上海第二医科大学瑞金医院!上海，200000 |
| 摘 要： | 目的 :研究细胞周期蛋白E有胃癌组织中的表达与细胞增殖活性及其它临床病理因素的关系。方法 :用免疫组织化学方法检测 40例胃癌组织中细胞周期蛋白E和Ki-6 7的表达。结果 :胃癌组织中细胞周期蛋白E和Ki-6 7表达阳性率分别为 45 %和 72 5 % ,在细胞周期蛋白E阳性胃癌中Ki-6 7阳性率明显高于细胞周期蛋白E阴性胃癌 (P <0 0 5 )。此外还发现细胞周期蛋白E在胃癌中的表达与肿瘤浸润深度、淋巴结转移和TNM分期密切相关 ( P <0 0 5 )。结论 :提示细胞周期蛋白E在胃癌中的表达与Ki-6 7的表达有关 ,并在肿瘤的进展中起一定作用 |
| 关 键 词： | 细胞周期蛋白E Ki-67 胃癌 免疫组织化学 |
EXPRESSION OF CYCLIN E IN GASTRIC CARCINOMAS AND ITS RELATIONSHIP WITH CELL PROLIFERATIVE ACTIVITY |
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| Xia Jiazeng,Wang Xinnan,Yang Jichang,et al.. EXPRESSION OF CYCLIN E IN GASTRIC CARCINOMAS AND ITS RELATIONSHIP WITH CELL PROLIFERATIVE ACTIVITY[J]. Journal of Clinical Medicine in Practice, 1999, 0(2) | |
| Authors: | Xia Jiazeng Wang Xinnan Yang Jichang et al. |
| Abstract: | Objective: Studying the Expression of cyclin E in gastric carcinomas and its relationship with cell proliferative activity and other pathological elements in clinic.Motheds:Expression of cyclin E and Ki-67 in 40 cases of gastric carcinomas was detected by immunohistochemical method.Results:The total positive expression rate of cyclin E and Ki-67 was 45% and 72.5%,respectively.The incidence of Ki-67 expression was higer in cyclin E positive tumors than in the other tumors.Inddition,cyclin E expression was observed frequetly in deeply invasive tumors with lymph node metastasis,and tumors with advanced stage.Conclusion:The expression of cyclin E correlates with Ki-67 expression and might contribute to the progression of gastric carcinoma. |
| Keywords: | cyclin E Ki-67 gastric carcinoma immunohistochemistry |
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