地塞米松诱导大鼠胰岛素抵抗机制的研究

观察了大鼠肌注地塞米松１周和３周后的空腹血糖、血清胰岛素及血浆胰高血糖素ｃＡＭＰ、ｃＧＭＰ水平。结果是经地主松处理后、１周组和３周组的大鼠血清胰岛素明显高于对照组；１周组血糖浓度无显著变化，３周组血糖浓度明显升高；血浆胰高血糖素水平无明显变化，未被高血糖，高胰岛素所抑制；１周组血浆ｃＧＭＰ明显下降；３组间的ｃＡＭＰ浓度差异无统计学意义。

Study on The Resistant Mechanism of Rat Insulin by Dexamethasone Induction

The article detected the levels of fasting plasma glucose, serum insulin, plasma glucagon, plasma cAMP and plasma cGMP in rat after dexamethasone injection for one-week group and three-week group, respectively. The results showed that the serum insulin levels both in one-week group and three-week group were markedly higher than in the control group. The plasma glucose levels were normal in one-week group, but significantly increased in three-week group. The plasma glucose levels were normal, not inhibited by the elevated plasma glucagon and insulin. There was a marked decrease in plasma cGMP levels in one-week group, whereas there was no significant difference in plasma cAMP levels among the three groups.