上饶地区淋病奈瑟菌临床耐药性分析

目的了解上饶地区近年淋病奈瑟菌（NG）的耐药特点及产β-内酰胺酶淋病奈瑟菌（PPNG）的流行状况,为本地区淋病治疗合理选用抗生素提供指导。方法采用K-B琼脂扩散法,测定临床分离鉴定的NG对8种常用抗生素的敏感性;应用硝基噻吩显色法检测PPNG。结果 116株NG对8种抗生素的耐药率从高到低依次为：氧氟沙星（91.4%）、四环素（83.6%）、氨苄青霉素（55.2%）、头孢噻吩（18.9%）、头孢呋辛（12.0%）、头孢噻肟（7.8%）、头孢曲松（6.9%）和大观霉素（4.3%）;检测出PPNG54株（46.6%）。结论氧氟沙星、四环素和氨苄青霉素不宜作为本地区淋病治疗药物,大观霉素和第三代头孢菌素可作为首选药物,但要加强耐药性检测。

Antibiotic resistance in clinical strains of Neisseria gonorrhoeae isolated in Shangrao area

Objective To survey the antibiotic resistance in clinical strains of Neisseria gonorrhoeae isolated in Shangrao area and provide guides for rational administration of antibiotics.Methods The susceptibility of clinical N.gonorrhoeae strains to 8 antibiotic angents was detected by the disk diffusion method and β-lactamase of penicillinase-producing neisseria gonorrhoeae（PPNG） determined by the Nitrocefin assay.Results From higher level to lower level in order,the resistance rates of 116 strains to ofloxacin,tetracycline,ampicillin,cefalotin,cefuroxime,cefotaxime,ceftriaxone and spectinomycin were 91.4%,83.6%,55.2%,18.9%,12.0%,7.8%,6.9% and 4.3%,respectively.PPNG accounted for 46.6%（54/116）.Conclusion Ofloxacin,tetracycline and ampicillin are unsuitable for treatment of gonorrhea as routine agents,spectinomycin and the third generation cephalosporin should be used as the first-line agents in treating gonorrhea in this area but resistance strains to these agents need more testing.