肝细胞癌组织CD44v6的检测及其临床意义

目的　探讨原发性肝细胞癌患者术后组织切片中CD44v6的表达及其临床意义。方法　通过免疫组化方法 ,用CD44v6的单克隆抗体 ,以S -P染色法检测CD44v6的表达。结果　CD44v6在癌组织中的表达显著高于癌旁组织 ,有肝外转移的患者其CD44v6的表达也明显高于没有转移的患者 ,而CD44v6的表达在肿瘤大小、分化程度、门静脉癌栓、两年内复发等方面没有显著性差异。结论　CD44v6与肝细胞癌的细胞恶变的发生有关 ,而且CD44v6在有肝外转移患者中的高表达说明它在肝癌发生转移中发挥重要作用。而CD44v6的表达与肿瘤大小、分化程度、门静脉癌栓及两年内复发无关。

Expression of CD44v6 in hepatocellular carcinoma and its clinical significance

Objective To study the expression and its significance of CD44v6 in hepatocellular carcinoma(HCC) patients.Methods By immunohistochemistry,monoclonal antibody of CD44v6 was to used to determine the expression of CD44v6,according to S-P staining method.Results The expression of CD44v6 was significantly higher in carcinoma tissues(23/51) than that of adjacent tissues (7/46).Also,the positive rate of CD44v6 in HCC with metastasis was higher than that without metastasis,80.0%(8/10) and 36.6%(15/41) respectively,being significant different.Whereas the expression of CD44v6 had no correlation with the tumor size,differentiation, portal tumor thrombus and recurrence within 2 years.Conclusion CD44v6 is probably responsible for the occurrence of HCC.The strong expression of CD44v6 in cases with metastasis indicates that CD44v6 plays a key role in metastasis.