| 探讨血清1，5-脱水葡萄糖醇和糖化血清蛋白对妊娠期糖代谢异常的诊断价值 |
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| 引用本文： | 陈益川,张德亭,朱勇,张红萍.探讨血清1，5-脱水葡萄糖醇和糖化血清蛋白对妊娠期糖代谢异常的诊断价值[J].检验医学,2008,23(3):268-270. |
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| 作者姓名： | 陈益川 张德亭 朱勇 张红萍 |
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| 作者单位： | [1]温州市第三人民医院检验科,浙江温州325000; [2]温州市第三人民医院妇产科,浙江温州325000 |
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| 摘 要： | 目的探讨糖化血清蛋白（GSP）及1，5-脱水葡萄糖醇（1，5-AG）在妊娠期糖代谢异常诊断中的价值。方法对正常妊娠组、糖筛查异常组及糖耐量异常组进行空腹葡萄糖、口服葡萄糖50g筛选、GSP、1，5-AG测定。结果糖筛查异常组GSP水平为（154±18）μmol／L、糖耐量异常组GSP水平为（157±26）μmol／L，与正常妊娠组（136±30）μmol／L]比较，差异有统计学意义（P〈0.01）。糖筛查异常组和糖耐量异常组1，5-AG水平分别为（57．3±30．2）μmol／L、（45．2±25．7）μmol／L，显著低于正常妊娠组水平（84．5±35．6）μmol／L，P〈0．01]。结论GSP、1，5-AG呵作为妊娠期糖代谢异常筛查及诊断指标。
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| 关 键 词： | 1 5-脱水葡萄糖醇 糖化血清蛋白 糖筛查异常 妊娠 糖耐量异常 |
| 文章编号： | 1673-8640(2008)03-0268-03 |
| 修稿时间： | 2007年9月10日 |
The diagnostic value of 1,5-Anhydro-D-glucitol and glucosylated serum protein in abnormal glucometabolism in pregnancy |
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| CHEN Yichuan,ZHANG Deting,ZHU Yong,ZHANG Hongping.The diagnostic value of 1,5-Anhydro-D-glucitol and glucosylated serum protein in abnormal glucometabolism in pregnancy[J].Laboratory Medicine,2008,23(3):268-270. |
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| Authors: | CHEN Yichuan ZHANG Deting ZHU Yong ZHANG Hongping |
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| Institution: | CHEN Yichuan,ZHANG Deting,ZHU Yong,ZHANG Hongping.(1.Department of Clinical Laboratory, The Third Hospital of Wenzhou, Zhejiang Wenzhou 325000, China ; 2. Department of Gynaecology and Obstetrics, The Third Hospital of Wenzhou, Zhejiang Wenzhou 325000, China) |
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| Abstract: | Objective To investigate the diagnostic value of glucosylated serum protein（GSP） and 1,5-Anhydro-D- glucitol （1,5-AG） in abnormal glucometabolism in pregnancy. Methods The fasting blood glucose （FBG）, 50 g glucose challenge test（ GCT）, GSP, 1,5-AG in normal pergnancy group, abnormal GCT pergnancy group and abnormal o- ral glucose tolerance test（OGTT） pregnancy group were determined. Results The levels of GSP in abnormal GCT preg-nancy group and abnormal OGTT group were （154±18） μmol/L, （157±26） μmol/L respectively, and they were significantly higher than that in normal pregnancy group （136±30]μmol/L,P 〈 0.01 ）. The levels of 1,5-AG abnormal GCT pregnancy group and abnormal OGTT group were （57.3±30.2）μmol/L and （45.2±25.7）μmol/L respectively, and they were significantly lower than that in normal pregnancy group （84.5±35.6 ] μmol/L, P〈0.01 ）. Conclusions GSP and 1,5-AG are indicators for screening and diagnosing pregnant glucometabolism abnormality. |
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| Keywords: | 1 5-Anhydro-D-glucitol Glucosylated serum protein Abnormal glucose challenge test Pregnancy Oral glucose tolerance test |
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