Cytotoxic T cells - stroma interactions |
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| Authors: | Noman Muhammad Zaeem Benlalam Houssem Hasmim Meriem Chouaib Salem |
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| Affiliation: | Inserm, PR1 and IFR, laboratoire d’immunologie des tumeurs humaines : interaction effecteurs cytotoxiques-système tumoral, Institut Gustave-Roussy, Villejuif, France. noman@igr.fr |
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| Abstract: | ![]()
The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators. This review discusses the potential role of hypoxia and endothelial cells within tumor microenvironment and emphasizes their interaction with antigen specific killer cells. |
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| Keywords: | hypoxia STAT3 HIF-1α endothelial cells tumor cells CTLs |
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