Plaque inhibitory effect of a 0.05% cetyl-pyridinium chloride mouth-rinse in a 4-day non-brushing model

To cite this article:
Int J Dent Hygiene 9 , 2011; 266–273 DOI: 10.1111/j.1601‐5037.2010.00490.x
García V, Rioboo M, Serrano J, O′Connor A, Herrera D, Sanz M. Plaque inhibitory effect of a 0.05% cetyl‐pyridinium chloride mouth‐rinse in a 4‐day non‐brushing model. Abstract: Objectives: Results from clinical studies evaluating the efficacy of the adjunctive use of cetyl‐pyridinium chloride (CPC) containing oral hygiene products have shown wide variability, probably due to differences in formulations. The objective of this study was to determine the inhibitory plaque effect of a 0.05% CPC mouth rinse in de novo plaque formation in a 4‐day non‐brushing experimental model. Materials and methods: The study was designed as a short‐term double‐blind randomized cross‐over experimental model aimed to compare three products: a negative control (similar to the test product, without active ingredients), a positive control (with 0.12% chlorhexidine and CPC) and the test product (with 0.05% CPC) in terms of plaque index, gingival inflammation and microbiological variables. Results: Plaque levels after 4 days were 2.88 for the positive control, 3.86 for the negative control and 3.60 for the test. Differences among groups on day 4 were statistically significant (P < 0.001). Gingival index showed comparable values at baseline (P = 0.745), and significant increases were observed, with the exception of the positive control. Total colony forming units showed comparable values at baseline (P = 0.125) and significant increases were observed only in the negative control. Conclusions: The tested 0.05% CPC mouth‐rinse is capable of inhibiting plaque formation.