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| 卵巢上皮性肿瘤中C—erbB—2的表达与临床意义 | |
| 引用本文： | 张一心,陈拓,王庆庆,姜胜华. 卵巢上皮性肿瘤中C—erbB—2的表达与临床意义[J]. 南通医学院学报, 2001, 21(3): 259-260 |
| 作者姓名： | 张一心 陈拓 王庆庆 姜胜华 |
| 作者单位： | 南通医学院附属医院肿瘤外科 |
| 摘 要： | 目的：探讨C－erbB-2在卵巢癌发生和发展中的作用。方法：应用免疫组化S－P法检测了C－erbB-2在58例卵巢浆液性囊腺癌，10例交界性浆液性囊腺瘤，13例浆液性囊腺瘤中的表达情况，结果：C－erbB-2的表达在良性瘤和癌之间差异显著（P＜0．001），而在放巢癌中的表达与组织分化和临床分期有关（P＜0．05，P＜0．001）。结论：C－erbB-2在卵巢癌的形成和发展中发挥着一定的作用，其检测对卵巢肿瘤的良恶性鉴别、 预后判断和指导治疗均有积极的意义。 |
| 关 键 词： | 卵巢肿瘤 卵巢上皮性肿瘤 C－erbB－2 基因表达 血管内皮生长因子 免疫组织化学 |
| 文章编号： | 1000-2057(2001)03-0259-02 |
| 修稿时间： | 2000-09-22 |
STUDY ON EXPRESSION AND CLINICAL SIGNIFICANCE OF C-erbB-2 IN OVARIAN SEROUS ADENOCYSTIC NEOPLASMS |
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| SHI Jianfei,SHI Gongsheng,HUANG Jianfei. STUDY ON EXPRESSION AND CLINICAL SIGNIFICANCE OF C-erbB-2 IN OVARIAN SEROUS ADENOCYSTIC NEOPLASMS[J]. ACTA Academiae Medicinae Nantong, 2001, 21(3): 259-260 | |
| Authors: | SHI Jianfei SHI Gongsheng HUANG Jianfei |
| Abstract: | Objective:To study the effects of the gene expression of C-erbB-2 on oncogenesis and progression of ovarian cancer.Methods:The expression of C-erbB-2 were examined immunohistochemically in 58 cases of ovarian serous cystadenocarcinoma,10 cases of borderline serous cystadenomas and 13 cases of serous cystadenocarcinoma.The relationships between the results and clinicopathological features were studied.Results:The expressions of C-erbB-2 in benign and malignant ovarian tumors were significantly different (P<0.01).The expression of C-erbB-2 in ovarian cystadenocarcinoma was associated with histologic grade and clinical stage (P<0.05,P<0.01).Conclusions:The experiment suggests that C-erbB-2 plays roles in oncogenesis and progression of ovarian cystadenocarcinoma.Detection of its gene protein has positive effects on malignancy determination,prognosis and treatment of ovarian tumors. |
| Keywords: | Ovarian serous adenocystic neoplasms C-erbB-2 Immunohistochemistry |
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