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2型糖尿病肾病患者尿足细胞标志蛋白和血管内皮生长因子水平与氧化应激的相关性
引用本文:董闪闪,张洁,刘璠,秘玉静,李欣盼,周慧敏. 2型糖尿病肾病患者尿足细胞标志蛋白和血管内皮生长因子水平与氧化应激的相关性[J]. 重庆医学, 2016, 0(10): 1334-1336. DOI: 10.3969/j.issn.1671-8348.2016.10.011
作者姓名:董闪闪  张洁  刘璠  秘玉静  李欣盼  周慧敏
作者单位:1. 河北医科大学第一医院 内分泌科,石家庄,050031;2. 河北医科大学第一医院 检验科,石家庄,050031
基金项目:河北省卫生厅重点科技研究计划(20130260)。
摘    要:
目的:探讨2型糖尿病(T2DM )并发不同程度肾病患者尿足细胞标志蛋白(PCX)和血管内皮生长因子(VEGF)水平变化,及其与氧化应激的关系。方法186例T2DM患者按照24 h尿清蛋白排泄率(UAER)分为单纯 T2DM 组(SDM 组,62例)、微量组(NA组,60例)、大量组(MA组,64例),另取24 h UAER正常者作对照(NC组,60例)。分别检测PCX、VEGF、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH‐px)和丙二醛(MDA)水平。结果与其他3组比较,MA组VEGF、PCX及MDA水平最高(P<0.01),SOD和GSH‐px水平最低(P<0.01,P<0.05)。VEGF、UAER、HbA1c是尿PCX的独立危险因素。结论糖尿病肾病患者尿PCX 及血VEGF 与氧化应激相关,氧化应激与足细胞的损伤密切相关。

关 键 词:糖尿病肾病  尿足细胞标志蛋白  血管内皮生长因子  氧化性应激

Association of urinary podocalyxin and vascular endothelial growth factor levels with oxidative stress in patients with type 2 diabetes nephropathy
Dong Shanshan,Zhang Jie,Liu Fan,Mi Yujing,Li Xinpan,Zhou Huimin. Association of urinary podocalyxin and vascular endothelial growth factor levels with oxidative stress in patients with type 2 diabetes nephropathy[J]. Chongqing Medical Journal, 2016, 0(10): 1334-1336. DOI: 10.3969/j.issn.1671-8348.2016.10.011
Authors:Dong Shanshan  Zhang Jie  Liu Fan  Mi Yujing  Li Xinpan  Zhou Huimin
Abstract:
Objective To investigate the change of urinary podocalyxin(PCX) and vascular endothelial growth factor (VEGF) levels and its association with the oxidative stress in the patients with type 2 diabetes mellitus(T2DM ) complicating dif‐ferent degrees of diabetic nephropathy .Methods Totally 186 patients with T2DM were divided into the pure T2DM (SDM ,62 ca‐ses) ,trace amount group(NA group ,60 cases) and massive amount group(MA group ,64 cases) according to the 24 h urinary albu‐min excretion rate(UAER) .60 cases of normal 24 h UAER were taken as the control group(NC group) .The levels of PCX ,VEGF , superoxide dismutase (SOD) ,malondialdehyde(MDA) and glutathione peroxidase (GSH‐px)were determined .Results Compared with other three groups ,the level of VEGF ,PCX and MDA in the MA group were highest(P<0 .01) ,while the levels of SOD and GSH‐px were lowest(P<0 .01 ,P<0 .05) .VEGF ,UAER ,HbA1c were the independent risk factors for urinary PCX .Conclusion In patients with diabetic nephropathy ,urinary PCX and VEGF are correlated with the oxidative stress ,while the oxidative stress is closely correlated with glomerular podocyte injury .
Keywords:diabetic nephropathy  podocytes  vascular endothelial growth factor  oxidative stress
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