川芎嗪对先天性心脏病肺动脉高压体外循环下血栓素A2及前列环素的影响

目的：探讨川芎嗪对先天性心脏病肺动脉高压患者全体上血栓素Ａ２（ＴＸＡ２）／前列环素（ＰＧＩ２）平衡的保护作用。方法：将３０例非紫绀型先天性心脏病肺动脉高压患者随机分为对照组（１５例）和用药组（１５例）。川芎嗪分别于麻醉诱导后静脉滴注３ｍｇ／ｋｇ及转流后加入氧合器中１ｍｇ／ｋｇ，分别于麻醉诱导后、转流１５ｍｉｎ、升主动脉开放５ｍｉｎ、停机后２０ｍｉｎ、６ｈ及２４ｈ采血并测定ＴＸＡ２、ＰＧＩ２。结果：

Effects in Tetramethylpyrazine on TXA2 and PGI2 by Cardio Pulmonary Bypass in Congenital Heart Diseases with Pulmonary Hypertension Patients

Objective: To study protective effects of tetramethylpyrazine (TMP) on the imbalance of TXA 2/PGI 2 during cardiopulmomary bypass (CPB) in congenital heart disease (CHD) with pulmonary hypertension (PH) patients. Methods: Thirty patients suffered from non cyanotic CHD PH were randomly divided into control group (n=15) and treatment group (n=15). 3 mg/kg of TMP was dripped intravenously after anesthesia and 1 mg/kg of TMP was infused into oxygenator after CPB individually. Blood samples were collected and TXA 2 as well as PGI 2 were measured after anesthesia induction, 15 min during CPB, 5 min after release of the aortic cross clamp,and 20 min, 6 hrs and 24 hrs after CPB. Results: There was significant difference between treatment group and control group except before operation and 24 hrs after CPB. Conclusions: The imbalance of TXA 2 and PGI 2 in patients with CHD PH during CPB could correct by TMP.