硫普罗宁片防治抗结核药物性肝损害的临床观察

目的观察硫普罗宁（凯西莱片）预防和治疗抗结核药物肝损害的疗效。方法选择住院及门诊确诊为活动性肺结核患者142例。观察凯西莱片预防和治疗抗结核药物肝损害情况。预防组72例，未预防组70例，预防组在抗痨基础上加服凯西莱片。抗痨基础上出现药物性肝损害共有49例，随机分成治疗组25例，对照组24例。治疗组口服凯西莱片，对照组口服齐墩果酸片。结果与未预防组相比较，预防组谷丙转氨酶（ALT）〉40U／L发生率和ALT升高时间明显降低，差异均有显著性（P〈0．05）。治疗药物性肝损害方面，治疗组ALT复常时间明显短于对照组，差异有显著性（P〈0．05）。结论凯西莱片对预防和治疗抗结核药物性肝损害有较好疗效，特别降酶效果显著，毒副作用少且易于耐受，安全性良好，值得临床推广应用。

Clinical observation of Tiopronin tablets prevention hepatic lesion of antituberculosis drugs

Objeetve To observe the curative effect of Tiopronin tablets prevention and cure lesion of antituberculosis drugs. Methods To choose the patients in hospital and out-patient （ n = 142 ） who all final diagnosis were active tuberculosis, havent hepatitis history and with norroal hepatic function before use antituberculosis drugs. All patients to separate the prevetion group （ n =72 ） and none provetion group （ n =70 ） by random. There have 49 patients appearance the medico - hepatic lesion at the foundation of use antituberculosis drugs. Then separate the 49 patients two groups by random： treat group （ n = 25 ） and control group （ n = 24 ）. The treat groups take orally Tiopronin tablets and the control groups take orally Oleanolic Acid. Results The time ALT takes to advance in the prevention group days is obviously lower than that in the none prevetion group（ P 〈0, 05 ）. In these patients who appearance the medico - hepatic lesion groups that the alanine aminotransferase values recover normal times for the treat groups days were significantly better when compared with control groups days（ P 〈 0.05 ） . Conclusion The Tiopronin tablets have good curative effect to prevention and cure medico - hepatic lesion by use antituberculosis drugs, especially it have significant effect to lower alanine aminotransferase and fewer of the adverse reaction and have fine safety.