亚胺培南-西司他丁钠致老年患者痫性发作

1例100岁男性患者,因肺炎给予亚胺培南-西司他丁钠0.5g加入0.9%氯化钠注射液100mL静脉滴注,1次/12h。第2次输注完毕2h后患者突然出现意识不清、双眼向上凝视、牙关紧闭、口唇发绀,HR126次/min,BP178/86mmHg,血氧饱和度80%。立即给予对症支持治疗,约4min后症状缓解。停用亚胺培南-西司他丁钠,改为美罗培南,10d后肺炎治愈。此后未再应用亚胺培南-西司他丁钠,未再出现痫性发作。

Imipenem/cilastatin sodium-induced epileptic seizure in an elderly patient

A 100-year-old male patient with pneumonia received an IV infusion of imipenem/cilastatin sodium 0.5 g in 0.9% sodium chloride 100 mL every 12 hours.Two hours after the second infusion completion,the patient suddenly presented with confusion,upward gaze,trismus,and cyanosis.His heart rate was 126 beats/min,blood pressure was 178/86 mm Hg,and oxygen saturation was 80%.Supportive and symptomatic treatment was given immediately and,about four minutes later,the symptoms improved.Imipenem/cilastatin sodium was withdrawn and changed to meropenem.Ten days later,his pneumonia was cured.Imipenem/cilastatin sodium were not given again and epileptic seizure did not recur anymore.