肺癌的遗传特质及表观遗传学变化

越来越多的证据表明在肺癌的发生、发展、转移等病理过程中,各种分子间的相互作用,多种易感因素、基因的高度甲基化、基因表达谱、EGFR途经等都与肿瘤息息相关.各型肺癌不仅具有独斗畴}的组织学差异,而且具有类似而又不同的遗传特质.在诊断,治疗及预后等方面必须考虑到各型肺癌的异质性,以肺癌的分子生物学改变作为诊断治疗的基础.此篇综述将重点讨论肺癌的遗传特质及其表观遗传学变化.

Genetic Characters and Epigenetic Changes of Lung Cancer

More and more evidences have showed that certain molecular events are involved in the development and metastasis of lung cancer.This includes the susceptibility factors,an association between genetic changes in EGFR pathway and tyrosine kinase inhibitors,the role of gene hypermethylation and gene expresison profile,as well as different molecular aspects of tumor progression.Available data all support that different thpe of lung cancer not only reveal diseases histological different but also different genetic characters.Accordingly,the diagnosis,prognosis and therapy must accommodate this heterogeneity.