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| 促凋亡蛋白Bim基因在白血病中的表达以及与铁蛋白的关系 | |
| 引用本文： | 龙石峰,陈三军. 促凋亡蛋白Bim基因在白血病中的表达以及与铁蛋白的关系[J]. 实用临床医学(江西), 2008, 9(3): 7-9 |
| 作者姓名： | 龙石峰 陈三军 |
| 作者单位： | 南昌大学研究生院医学部 2005级(龙石峰)，南昌大学第二附属医院血液科 南昌330006(陈三军) |
| 摘 要： | 目的 研究白血病患者与其骨髓中促凋亡蛋白Bim基因表达的关系，以及Bim基因的表达与血清铁蛋白水平的关系。方法用半定量RT—PCR方法检测30例白血病患者和10例特发性血小板减少性紫瘢（ITP）患者（对照组）中BimmRNA的表达，并分析其与血清铁蛋白水平的关系。结果白血病患者和对照组中均存在BimmRNA的表达，但白血病患者BimmRNA的表达明显低于对照组（P＜0．01），与铁蛋白成负相关性（Y=1237．6-1280X，r=-1280）。结论BimmRNA在白血病患者中呈低表达，与白血病的发生密切相关，Bim的促凋亡机制和细胞内铁吸收转运有关。 |
| 关 键 词： | 白血病 凋亡 铁蛋白 Bim |
| 文章编号： | 1009-8194(2008)03-0007-03 |
| 修稿时间： | 2007-11-13 |
Relationship between Expressions of Proapototic Protein Bim and Ferritin in Leukemia |
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| LONG Shi-feng,CHEN San-jun. Relationship between Expressions of Proapototic Protein Bim and Ferritin in Leukemia[J]. Practical Clinical Medicine, 2008, 9(3): 7-9 | |
| Authors: | LONG Shi-feng CHEN San-jun |
| Affiliation: | LONG Shi-feng,CHEN San-jun(a. 2005 Grade Department of Medical ,Graduate School ; b. Department of Haematology ,the Second Affiliated Hospital, Nanchang University, Nanchang 330006 ,China) |
| Abstract: | Objective To investigate the relationship between expression of Bim mRNA and intracelular iron delivery in leukemia patients,to reveal the machanism of apoptosis of Bim.Methods The expression of Bim mRNA in bone marrow mononuclear cell was detected by semi-quantaitaton RT-PCR technique in 30 leukemia patients and 10 normal controls.At the same time observe the ferritin in blood.Results Bim mRNA was expressed in all groups.By statistical analysis,the expression in leukemia patients was significantly lower than that in normal controls(P<0.01).The ferritin in leukemia patients' blood was negatively correlated with expression of Bim mRNA(Y=1 237.6-1 280X,r=-1 280).Conclusion Expression of Bim mRNA was negative to leukemia.The machanism of apoptosis of Bim protein was related to intracelular iron delivery. |
| Keywords: | leukemia apoptosis ferritin Bim |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |