| 抗流感病毒药物和病毒耐药性 |
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| 引用本文： | 张兴权,范江.抗流感病毒药物和病毒耐药性[J].传染病信息,2011,24(2):124-128. |
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| 作者姓名： | 张兴权 范江 |
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| 作者单位： | 张兴权,ZHANG Xing-quan(美国加州大学圣地亚哥医学院,拉霍亚,92093);范江,FAN Jiang(美国威斯康星医学院中西部呼吸道病毒项目组,尔沃基,53213密) |
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| 摘 要： | M2蛋白通道阻断剂金刚烷胺(amantadine)和金刚乙胺(rimantadine)在体内外均可迅速产生耐药和交叉耐药,机制是源于M2蛋白转膜区突变,涉及的5个主要氨基酸残基是26、27、30、31和34位.神经氨酸酶抑制剂磷酸奥司他韦(oseltamivir)、扎那米韦(zanamivir)和帕那米韦(parami...
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| 关 键 词： | 神经氨酸酶 酶抑制剂 抗药性 基因突变 |
Anti-influenza virus agents and drug resistance |
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| ZHANG Xing-quan,FAN Jiang.Anti-influenza virus agents and drug resistance[J].Infectious Disease Information,2011,24(2):124-128. |
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| Authors: | ZHANG Xing-quan FAN Jiang |
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| Institution: | San Diego Medical School,University of California,La Jolla 92093,USA |
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| Abstract: | Resistance and cross-resistance of influenza A virus to M2 inhibitors adamantane and rimantadine can emerge ra-pidly during treatment in vitro and in vivo.A single point mutation in the codons for amino acids at positions 26,27,30,31,or 34 of the M2 protein can confer the resistance and cross-resistance to both amantadine and rimantadine.Drug resistance emergency in use of neuraminidase(NA) inhibitors,oseltamivir,zanamivir and paramivir is caused by the change of the NA at residues 119,274,292(type A) and 152(type B).So far no any influenza virus strain has been found to be resistant to all chemotherapeutic drugs.The studies on new NA inhibitors and drugs directed to other targets are now in trial period. |
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| Keywords: | neuraminidase enzyme inhibitors drug resistance gene mutation |
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