肝脏局灶性结节性增生34例诊治分析

目的 探讨肝脏局灶性结节性增生的临床表现、治疗方法和预后.方法 回顾性分析我院经手术治疗的34例肝脏局灶性结节性增生患者的临床资料.结果 本组男性发病居多(67.6%),发病时男性较女性肿物直径小,患者多无临床症状(64.7%),32例为单发病灶,2例为多发病灶,肿瘤标记物CA199,AFP正常,术前MRI检查有较高的诊断准确率,为54.5%.34例患者均经手术切除,经随访17～134个月,无复发.结论 FNH如能诊断准确,可随访观察,如确诊困难、有明显临床症状、短期增长速度较快,首选手术治疗,预后良好.

Abstract：

Objective To investigate the clinical features,therapeutic approach and prognosis of focal nodular hyperplasia (FNH) of the liver. Methods Clinical data of 34 FNH patients confirmed by operation were analyzed retrospectively. Results Focal nodular hyperplasia of the liver was found mainly in males (67. 6% ) , Mean nodular size was significantly smaller in men than women. Most of the patients (64.7%) had no significant clinical symptoms. Tumor markers including CA19-9 and A-fetoprotein were within normal range. MRI is helpful to achieve a more accurate diagnosis of the disease, correct preoperative diagnosis rate was 54. 5%. All patients underwent liver resection with no recurrence within 17 - 134 months of follow up. Conclusions FHN of the liver is benign in entity. If a definite diagnosis can be obtained preoperatively, observation follow-up are recommended. Hepatectomy is indicated when there is a suspicion of malignancy.

Diagnosis and treatment for focal nodular hyperplasia of the liver:report of 34 cases

Objective To investigate the clinical features,therapeutic approach and prognosis of focal nodular hyperplasia (FNH) of the liver. Methods Clinical data of 34 FNH patients confirmed by operation were analyzed retrospectively. Results Focal nodular hyperplasia of the liver was found mainly in males (67. 6% ) , Mean nodular size was significantly smaller in men than women. Most of the patients (64.7%) had no significant clinical symptoms. Tumor markers including CA19-9 and A-fetoprotein were within normal range. MRI is helpful to achieve a more accurate diagnosis of the disease, correct preoperative diagnosis rate was 54. 5%. All patients underwent liver resection with no recurrence within 17 - 134 months of follow up. Conclusions FHN of the liver is benign in entity. If a definite diagnosis can be obtained preoperatively, observation follow-up are recommended. Hepatectomy is indicated when there is a suspicion of malignancy.