| HBV相关慢加急性肝衰竭患者血乳酸水平影响因素分析 |
| |
| 引用本文： | 陈婧,胡瑾华,刘晓燕,段学章,何卫平,王慧芬. HBV相关慢加急性肝衰竭患者血乳酸水平影响因素分析[J]. 传染病信息, 2011, 24(3): 156-158,184 |
| |
| 作者姓名： | 陈婧 胡瑾华 刘晓燕 段学章 何卫平 王慧芬 |
| |
| 作者单位： | 陈婧,胡瑾华,CHEN Jing,HU Jin-hua(100853北京,解放军军医进修学院;100039,北京,解放军第三○二医院肝衰竭治疗研究中心);刘晓燕,段学章,何卫平,王慧芬,LIU Xiao-yan,DUAN Xue-zhang,HE Wei-ping,WANG Hui-fen(解放军第三○二医院肝衰竭治疗研究中心,北京,100039) |
| |
| 基金项目： | 中美重大肝病合作计划，国家"十一五"科技重大专项，首都医学发展科研基金重点课题 |
| |
| 摘 要： | 目的观察HBV相关慢加急性肝衰竭（HBV—relatedacute-on—chronic liver failure，HBV—ACLF）患者接受核苷类似物抗病毒治疗过程中血清乳酸的变化并探讨其意义。方法回顾性分析2009---2010年于我院治疗的74例HBV—ACLF患者的临床资料，分析乳酸升高与核苷类似物、感染、肝肾综合征以及生化指标的关系。结果服用恩替卡韦或拉米夫定的2组患者乳酸升高比率的差异无统计学意义。乳酸水平升高与感染、肝肾综合征的发生有关（X^2值分别为9．417和6．158，P值分别为0．002和0．013）。临床无确切引起乳酸升高原因的3例患者，乳酸呈一过性升高，且预后良好。结论HBV-ACLF患者抗病毒治疗过程中乳酸升高主要原因是感染和肝肾综合征。核苷类似物治疗HBV—ACLF未引发显著的乳酸升高，安全性良好。
|
| 关 键 词： | 乙型肝炎 慢加急性肝衰竭 乳酸 抗病毒治疗 核苷类似物 |
Factors affecting serum lacticemia level in patients with HBV-related acute-on-chronic liver failure |
| |
| CHEN Jing,HU Jin-hua,LIU Xiao-yan,DUAN Xue-zhang,HE Wei-ping,WANG Hui-fen. Factors affecting serum lacticemia level in patients with HBV-related acute-on-chronic liver failure[J]. Infectious Disease Information, 2011, 24(3): 156-158,184 |
| |
| Authors: | CHEN Jing HU Jin-hua LIU Xiao-yan DUAN Xue-zhang HE Wei-ping WANG Hui-fen |
| |
| Affiliation: | CHEN Jing,HU Jin-hua *,LIU Xiao-yan,DUAN Xue-zhang,HE Wei-ping,WANG Hui-fen Chinese PLA Postgraduate Medical College,Beijing 100853,China |
| |
| Abstract: | Objective To evaluate the changes of serum lactate level and its significance in patients with HBV-related acute-on-chronic liver failure(HBV-ACLF) receiving nucleoside analogue antiviral therapy.Methods Clinical data of 74 HBV-ACLF pa-tients treated in our hospital from 2009 to 2010 were retrospectively analyzed,and the relationship between increased serum lactate level and nucleoside analogues,infection,hepatorenal syndrome and biochemical indicators were evaluated.Results The propor-tions of the patients... |
| |
| Keywords: | hepatitis B acute-on-chronic liver failure lacticemia antiviral therapy nucleoside analogues |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
