| 几种抗氧化剂对甲基汞所致神经损伤的防治作用 |
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| 引用本文： | 刘巍,徐兆发. 几种抗氧化剂对甲基汞所致神经损伤的防治作用[J]. 中国工业医学杂志, 2011, 24(4): 276-279 |
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| 作者姓名： | 刘巍 徐兆发 |
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| 作者单位： | 中国医科大学公共卫生学院环境卫生学教研室; |
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| 摘 要： | 甲基汞主要造成中枢神经系统损伤,其机制尚未被完全阐明,氧化损伤可能是甲基汞所致神经毒性的重要病因。抗氧化剂是一类低毒高效,具有多种生物活性的物质,本文就甲基汞所致脑氧化损伤的机制及几种抗氧化剂的抗氧化机制进行简要介绍,为甲基汞中毒的防治提供理论参考。
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| 关 键 词： | 甲基汞 氧化损伤 还原型谷胱甘肽 N-乙酰半胱氨酸 茶多酚 五味子乙素 |
Research progress on antioxidants against neurotoxicity induced by methylmercury |
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| LIU Wei,XU Zhao-fa. Research progress on antioxidants against neurotoxicity induced by methylmercury[J]. Chinese Journal of Industrial Medicine, 2011, 24(4): 276-279 |
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| Authors: | LIU Wei XU Zhao-fa |
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| Affiliation: | LIU Wei,XU Zhao-fa(Department of Environmental Health,School of Public Health,China Medical University,Shenyang 110001,China) |
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| Abstract: | Brain is the main target organ poisoned by methylmercury,the mechanism of the neurotoxicity is still not quite clear.It was suggested that oxidative damage might play a key role in methylmercury induced neurotoxicity.Antioxidants are a kind of the substances with low toxicity and high bioactivity.In this paper,the mechanisms of neurotoxicity casued by methylmercury and the antagonistic effect of antioxidants were reviewed. |
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| Keywords: | methylmercury oxidative injury reduced glutathione N-acetylcysteine tea polyphenols schisandrin B |
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