| The Changes of TGF-α, TGF-β_1 and Basic FGF Messenger RNA Expression in Rabbit Cornea after Photorefractive Keratectomy |
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| 作者姓名： | Yisheng Zhong Feng Cheng Yingming Zhou Jingcai Lian Wen Ye Kangsun WangOphthalmic Center Ruijin Hospital Shanghai Second Medical University Shanghai 200025 ChinaThe Research Center for Human Gene Therapy Shanghai Second Medical University Shanghai 200025 China |
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| 作者单位： | Yisheng Zhong,Feng Cheng,Yingming Zhou,Jingcai Lian,Wen Ye,Kangsun WangOphthalmic Center,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,ChinaThe Research Center for Human Gene Therapy,Shanghai Second Medical University,Shanghai 200025,China |
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| 摘 要： | ![]()
Objective : To study the mechanism of haze formation and investigate the expression changes of transforming growth factor-α(TGF-α), transforming growth factor-β1 (TGF-β1) and basic fibroblast growth factor (bFCF) mRNA in corneal epithelium and stroma after photorefractive keratectomy (PRK).Methods: Sixteen white rabbits were randomly divided into 4 groups, and PRK was performed on each eye of 12 rabbits. The haze formation was examined under a slit-lamp microscope at the 1st, 2nd and 3rd month after PRK, and the expressions of TGF-α , TGF-β1 and bFGF mRNA were detected with in situ hybridization.Results : The corneal haze formed at the 1" month after PRK. The most prominent haze formation was observed at the 2nd month, and declined gradually at the 3rd month after ablation. TGF-a mRNA expression was presented on the normal corneal epithelium and not on the corneal stroma. TGF-β1 and bGFG mRNA were expressed by both corneal epithelium and stroma. The capacities for cornea tissue expression of thre
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| 关 键 词： | photorefractive keratectomy wound healing transforming growth factor-α transforming growth factor-Pi basic fibroblast growth factor |
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