| The Analysis of Pedigree GZ（Guangzhou）.1 with Primary Open Angle Glaucoma |
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| 引用本文： | YehongZhuo MeiWang 等. The Analysis of Pedigree GZ（Guangzhou）.1 with Primary Open Angle Glaucoma[J]. 眼科学报, 2000, 16(1): 53-55 |
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| 作者姓名： | YehongZhuo MeiWang 等 |
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| 作者单位： | [1]ZhongshanOphatalmicCenter,SunYet－senUniversityofMedicalSciences,Guangzhou510060 [2]SunYet－senHospital,Su |
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| 基金项目： | Supported by grants from Nature Science Fundation of China(No.39770789,39800163),Guangdong province (No.980112) |
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| 摘 要： | Purpose:To analyze the hereditary modality of primary open-angle glaucoma in China.Methds:The genetic form of Pedigree GZ.1was analyzed using Mandalian hereditary rules.Results:PedigreeGZ.1 had following characteristics:1)The pedigree had four gene-rations,and there existed POAG patients in each generation;2)Each patient had a parent withPOAG.Ifthparents didn‘t suffer from the disease,their children would not.3)The incidence of POAG in the relatives of the patients was1/2,In addition,The age of onset,intraocular pressure,fundus and prognosis was different from each other in the patients.Conclusions:1)Pedigree GZ.1 is inherited as an autosomal dominant trait.2)There exists individual differences of clinical manifestations in POAG patients,Eye Science2000;16:53-55.
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| 关 键 词： | 原发性青光眼 广州 家系 遗传病理学 |
The Analysis of Pedigree GZ (Guangzhou) . 1with Primary Open Angle Glaucoma |
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| Yehong Zhuo,Jian Ge,Mci Wang,Haiquan Liu,Minkai Lin. The Analysis of Pedigree GZ (Guangzhou) . 1with Primary Open Angle Glaucoma[J]. Eye science, 2000, 16(1): 53-55 |
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| Authors: | Yehong Zhuo Jian Ge Mci Wang Haiquan Liu Minkai Lin |
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| Affiliation: | 1. Zhongshan Ophthalmic Center, Sun Yet-sen University of Medical Sciences, Guangzhou 510060, China
2. Sun Yet-sen Hospital, Sun Yet-sen University of Medical Sciences, Guangzhou 510060, China |
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| Abstract: | Purpose: To analyze the hereditary modality of primary open-angle glaucoma in China. Methods: The genetic form of Pedigree GZ. 1 was analyzed using Mandalian hereditary rules.Results: Pedigree GZ. 1 had following characteristics: 1) The pedigree had four generations, and there existed POAG patients in each generation; 2) Each patient had a parent with POAG. If the parents didn't suffer from the disease, their children would not. 3) The incidence of POAG in the relatives of the patients was 1/2. In addition, The age of onset, intraocular pressure, fundus and prognosis was different from each other in the patients.Conclusions: 1) Pedigree GZ. 1 is inherited as an autosomal dominant trait. 2) There exists individual differences of clinical manifestations in POAG patients. Eye Science 2000; 16: 53 - 55. |
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| Keywords: | primary open-angle glaucoma pedigree GZ. 1 |
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