肝硬化腹水低钠血症的临床研究

目的研究肝硬化腹水低钠血症合理有效的治疗方法．址补钠还是限钠。方法将146例肝硬化腹水低钠血症患者随机分成补钠和限钠治疗两组，观察比较两组的血钠、尿钠、PRA、AⅡ、ALD、利尿效果、腹水消退、肾功能损害情况和肝性脑病、HRS发生率和死亡率。结果与限钠组相比，补钠组血钠、尿钠升高，PRA、AⅡ、ALD活性下降，尿量增多明显，腹水消退较快，肾功损害、肝性脑病、HRS发生率和死亡率均较低。结论治疗肝硬化腹水低钠血症应适量补钠。

A clinical study on cirrhosis with ascites and hyponatremia

Objective To study the reasonable and effectiveness therapy in cirrhotic patients with ascites and hyponatremia is Na supplement or limitation. Methods 146 cirrhotic patients with ascites and hyponatremia were divided into two groups randomly, to observe the plasma sodium, urine sodium, PRA, AⅡ, ALD, diuretic effect, ascites subsided, renal dysfunction, hepatic encephalopathy, HRS incidence and mortality in the two groups. Results Comparing with the Na hmitation group, the plasma sodium and urine sodium increased, and the activity of PRA, A Ⅱ and ALD decreased, urine output increased significantly, ascetes subsided quickly, renal damage,heap-tic encephalopathy, HRS incidence and mortality were lower in the Na supplement group. Conclusion The treatment of the patients with ascites and hyponatremia should be limited amount of sodium.