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| 原发性支气管肺癌MRI信号强度与DNA含量的关系 | |
| 引用本文： | 许冬明,陈九如,杨振燕,詹松华,汤如勇,李日乐. 原发性支气管肺癌MRI信号强度与DNA含量的关系[J]. 中国医学影像学杂志, 2000, 8(2): 131-133,108 |
| 作者姓名： | 许冬明 陈九如 杨振燕 詹松华 汤如勇 李日乐 |
| 作者单位： | 1. 上海市闸北区中心医院放射科,上海,200070 2. 上海市甘泉医院放射科,上海,200065 3. 甘泉医院病理科,上海,200065 |
| 摘 要： | 目的探讨肺癌MRI信号强度与DNA倍体的关系.材料与方法26例肺癌患者,术前用Resonex0.38T磁共振成像系统,行横断面SET1加权,GR序列成像,增强后行SET1加权成像.术后标本用ICM-100细胞图像分析仪,测定该例肺癌的DNA含量及SPF值.结果T1加权平扫二倍体肿瘤信号强度比(病变/椎体)显著小于异倍体肿瘤的信号强度比.二倍体肿瘤的SP值也显著小于异倍体肿瘤的SPF值.但肿癌MRI信号强度比不能反映其SPF值.结论MRI信号强度在一定程度上可反映肿瘤细胞的倍体情况,即可间接地反映肿瘤细胞的生物学行为. |
| 关 键 词： | 肺癌 MRI信号强度 DNA含量 s期分数 |
| 修稿时间： | 1998-10-06 |
Investigation on the Relationship of MRI Signal Intensity and DNA Content of Lung Cancer |
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| Xu Dongming, Chen Jiuru, Yang Zhenyan, Zan Songhua, Tang Ruyong, Li Rile. Investigation on the Relationship of MRI Signal Intensity and DNA Content of Lung Cancer[J]. Chinese Journal of Medical Imaging, 2000, 8(2): 131-133,108 | |
| Authors: | Xu Dongming Chen Jiuru Yang Zhenyan Zan Songhua Tang Ruyong Li Rile |
| Abstract: | Purpose:To explore the relationship of MRI signal intensity and DNA content of lung cancer. Materials and Methods: Twen ty-six cases of lung cancer proved by surgery and pathology were examined with a 0.38T MR system before operation. The pulse sequences includ SE T_1WI, gradient echo and gadolinium(Gd-DTPA)-enhanced SE T_1WI sequences. DNA content was measured by a imaging analyz er(ICM-100)and the SPF percentage (S Phase Fraction)was calculated. Results: Signal-intensity ratios of lesion to vertebra on unenhanced SE T_1WI and SPF percentage were significantly smaller in diploid lesions than in aneuploid lesions. But MRI signal intensity ratify can not reflect SPF status. Conclusion: MRI signal-intensity ratios can reflect DNA ploidy in a certain degree, therefore, indirectly reflecting the ma lignant biological behavior of lung cancer. |
| Keywords: | lung cancer MRI signal intensity DNA content S Phase Fraction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |