In vitro evaluation of the cytotoxicity of calcium hydroxide-based root canal sealers |
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| Authors: | P. Beltes E. Koulaouzidou V. Kotoula A. H. Kortsaris |
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| Affiliation: | Department of Dental Pathology and Therapeutics, Aristotle University Theagenion Cancer Institute, Thessaloniki, Greece |
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| Abstract: | ![]()
Abstract The cytotoxicity of three calcium hydroxide-containing root canal sealers (Sealapex, CRCS and Apexit) was tested by using L929 and BHK 21/CIS cells. After setting for 24h, the sealers were covered with cell suspension. Cytotoxicity was determined by a quantitative technique at 24h, 48h and 72h. All the sealers were found to be cytotoxic. Sealapex showed the highest cytotoxicity, causing a significant decrease in cell density. CRCS was less toxic than Sealapex and more toxic than Apexit. Apexit proved to be the least toxic material. |
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| Keywords: | cytotoxicity sealers calcium hydroxide |
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