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| Therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation in rats | |
| 引用本文： | 张连阳,王正国,朱佩芳,徐琰. Therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation in rats[J]. 中华创伤杂志(英文版), 2005, 8(2): 101-104 |
| 作者姓名： | 张连阳 王正国 朱佩芳 徐琰 |
| 作者单位： | General Surgery Department，Daping Hospital，Research Institute of Field Surgery，Third Military Medical University，Chongqing 400042，China，4th Laboratory，Daping Hospital，Research Institute of Field Surgery，Third Military Medical University，Chongqing 400042，China，4th Laboratory，Daping Hospital，Research Institute of Field Surgery，Third Military Medical University，Chongqing 400042，China，General Surgery Department，Daping Hospital，Research Institute of Field Surgery，Third Military Medical University，Chongqing 400042，China |
| 摘 要： | Whenshockandtraumaoccur, stomachisoneofthetargetorganswhichcaneasilybeharmed,1acutegastricmucosalesionisalatentandfatalthreattothoseclinicalcriticallyillpatients.Aresearchshowsthattreatmentofgastricmotilityishelpfultoreducedeathrateofcriticallyillpatients… |
| 关 键 词： | 胃损伤 出血性炎症 小鼠 动物实验 药物治疗 |
Therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation in rats |
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| ZHANG Lian-yang,WANG Zheng-guo,Zhu Pei-fang,XU Yan. Therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation in rats[J]. Chinese journal of traumatology, 2005, 8(2): 101-104 | |
| Authors: | ZHANG Lian-yang WANG Zheng-guo Zhu Pei-fang XU Yan |
| Affiliation: | 1. General Surgery Department, Daping Hospital, Research Institute of Field Surgery, Third Military Medical University, Chongqing 400042, China 2. 4th Laboratory, Daping Hospital, Research Institute of Field Surgery, Third Military Medical University, Chongqing 400042, China |
| Abstract: | OBJECTIVE: To investigate the therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation. METHODS: 108 Wistar rats weighing (200 g+/-30 g) were randomly divided into a sham shock (SS) group (n=36), a hemorrhagic shock resuscitation (HS) group (n=36) and a hemorrhagic shock cisapride treated (HSC) group (n=36). Sampling at 1, 2 and 4 hours after resuscitation was done and 6 samples for each observation item were taken. The gastric blood flow volume was measured by isotope label biological microglobulin. Gastric pHi, gastric emptying, MDA and Na+-K+-ATPase of gastric mucosa were measured. RESULTS: In the HSC group, the relative residual rate of gastric pigment decreased significantly, the gastric blood flow volume elevated; gastric pHi increased significantly at 2 hours; the level of mucosal MDA decreased at 4 hours, the activity of Na+-K+-ATPase increased and the lactic acid level in the portal vein decreased significantly compared to the HS group. CONCLUSIONS: After hemorrhagic shock resuscitation, cisapride contained the following functions, 1) promoting gastric emptying, 2) increasing the blood flow of gastric blood flow volume and gastric pHi, 3) depressing the lactic acid concentration of the portal vein and improving MDA volume and Na+-K+-ATPase activity of gastric mucosa. It suggests that after complementing effective circulating blood volume for hemorrhagic shock resuscitation, early use of cisapride for gastric motility is helpful for an improvement of lasting ischemia and hypoxia in stomach. |
| Keywords: | Shock hemorrhagic Resuscitation Stomach Blood flow velocity Cisapride |
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