| 多奈哌齐治疗血管性痴呆的疗效 |
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| 引用本文： | 潘大津,徐哲明,吴绍长,朱满莲,叶双樱,程英. 多奈哌齐治疗血管性痴呆的疗效[J]. 中国新药与临床杂志, 2006, 25(1): 11-13 |
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| 作者姓名： | 潘大津 徐哲明 吴绍长 朱满莲 叶双樱 程英 |
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| 作者单位： | 1. 温州医学院,浙江,温州,325000
2. 丽水市第二人民医院,浙江,丽水,323000 |
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| 摘 要： | 目的: 观察多奈哌齐治疗轻、中度血管性痴呆病(vascular dementia,VaD)的疗效。方法:轻、中度 VaD病人69例完成验证,其中多奈哌齐组35例[男性27例,女性8例,年龄(70±s 6)a]用多奈哌齐片剂 5 mg,po,qd;安慰剂组34例[男性26例,女性8例,年龄(70±7)a]用安慰剂(维生素C)1片,po,qd。2组总疗程均为8 wk。结果:2组的临床有效率分别为74％和18％,2组比较差异有非常显著意义(P<0．01)。多奈哌齐组的不良反应轻微。结论:多奈哌齐治疗轻、中度VaD有效。
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| 关 键 词： | 痴呆 血管性 多奈哌齐 药物疗法 随机对照试验 |
| 文章编号： | 1007-7669（2006）01-0011-03 |
| 收稿时间： | 2005-08-10 |
| 修稿时间： | 2005-08-102005-10-30 |
Effects of donepezil in treatment of vascular dementia |
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| PAN Da-jin,XU Zhe-ming,WU Shao-chang,ZHU Man-lian,YE Shuang-ying,CHENG Ying. Effects of donepezil in treatment of vascular dementia[J]. Chinese Journal of New Drugs and Clinical Remedies, 2006, 25(1): 11-13 |
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| Authors: | PAN Da-jin XU Zhe-ming WU Shao-chang ZHU Man-lian YE Shuang-ying CHENG Ying |
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| Abstract: | AIM: To observe the clinical efficacy of donepezil in treating mild to moderate vascular dementia (VaD). METHODS: Sixty-nine patients with mild to moderate VaD completed the trial.Donepezil group (n=35,M 27,F 8;age(70±s6) a) were treated with donepezil,5 mg,po,qd. Placebo group (n = 34,M 26, F 8; age (70±7) a) were treated with placebo (vitamin C),1 tablet, po,qd . The whole course of treatment for each group was 8 wk. RESULTS: The clinical efficacies were 74 % and 18 % for donepezil and placebo groups,respectively, demonstrating significant difference between the two groups (P < 0.01). Adverse reactions of doneperil were mild. CONCLUSION: Donepezil is effective in treating mild to moderate VaD patients. |
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| Keywords: | dementia, vascular donepezil drug therapy randomized controlled trials |
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