| L-苹果酸对睡眠剥夺大鼠学习记忆的影响 |
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| 引用本文： | 邓龙祥,陈况,叶初阳,王黎平,刘芳娥. L-苹果酸对睡眠剥夺大鼠学习记忆的影响[J]. 中国现代药物应用, 2012, 6(20): 12-13 |
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| 作者姓名： | 邓龙祥 陈况 叶初阳 王黎平 刘芳娥 |
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| 作者单位： | 1. 第四军医大学口腔医学系,西安,710032
2. 第四军医大学基础部,西安,710032 |
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| 摘 要： | 目的探讨L-苹果酸对睡眠剥夺(SD)大鼠学习记忆的影响。方法 16只大鼠随机分为对照组(SD+生理盐水)和实验组(SD+L-苹果酸),用多平台水环境法建立大鼠SD模型,SD48h和SD72h后用Morris水迷宫测试大鼠的记忆能力。结果实验组大鼠的SD48h和SD72h水迷宫反应时均明显小于对照组。结论 L-苹果酸能改善睡眠剥夺的大鼠学习记忆能力。
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| 关 键 词： | 睡眠剥夺 L-苹果酸 学习记忆 |
Effect of L-malate on cognitive function of sleep deprivation rat |
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| Affiliation: | DENG Long-xiang , CHEN Kuang , YE Chu-yang,et al. The Dental Hygiene of The Fourth Military Medical University,Xi＇ an 710032, China |
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| Abstract: | Objective To explore the effect of L-malate on cognitive function of rat with sleep depriva- tion （SD）. Methods 20 rats were divided into control group （ SD ＋ sodium chloride） and experimental group （ SD ＋ L-malate ）. We use the modified multiple platform method to form the model, and after SD48 h and SD72 h we measure the rats＇ memory in the water maze. Results Compared with control group, the response time of experiment group in 48 or 72 water maze test decreased obviously. Conclusion L-malate can improve the cognitive function of sleep deprivation rat. |
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| Keywords: | Sleep deprivation L-malate Cognitive function |
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