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| Cu,Zn SOD in Shandong families withamyotrophic lateral sclerosis | |
| 引用本文： | GU Hong-yan ZHANG Feng-zhen JIANG Han-Ming SUN Ling-Yun ZAI Jing ZHANG Yuan-ying. Cu,Zn SOD in Shandong families withamyotrophic lateral sclerosis[J]. 泰山医学院学报, 2004, 25(4): 339-340 |
| 作者姓名： | GU Hong-yan 3" > 3" face=" Times New Roman" >ZHANG Feng-zhen 3" > 3" face=" Times New Roman" >JIANG Han-Ming 3" > 3" face=" Times New Roman" >SUN Ling-Yun 3" > 3" face=" Times New Roman" >ZAI Jing 3" > 3" face=" Times New Roman" >ZHANG Yuan-ying 3" > |
| 作者单位： | GU Hong-yan（Dept.of Biochemistry,Taishan Medical College, Taian271000,China） ZHANG Feng-zhen（Dept.of Biochemistry,Taishan Medical College, Taian271000,China） JIANG Han-Ming（Dept.of Biochemistry,Taishan Medical College, Taian271000,China） SUN Ling-Yun（Dept.of Biochemistry,Taishan Medical College, Taian271000,China） ZAI Jing（Dept.of Biochemistry,Taishan Medical College, Taian271000,China） ZHANG Yuan-ying（Dept.of Biochemistry,Taishan Medical College, Taian271000,China） |
| 摘 要： | In 1993,mutationsinthegenewhichencodesthecytosolicCu ,Znsuperoxidedismutase (SOD )couldbefoundinabout 30 %ofAmerican patientswiththefamilialformofamyotrophiclateralsclerosis(FALS) [1,2 ] Mutationshavebeendescribedinexons1,2 ,4and 5andareassociatedwithareducedactiv ityoftheCu ,ZnSOD (SOD)inerythrocytes[3 ] Incontrast,nomutationsintheSODgenehavebeendetectedineitherFrench[4] orDutchfamilies[5] Itwastheaimofourinvestigationstoexaminemuta tionsabouttheaminoacidanalysisofCu ,ZnSODprote… |
Cu,Zn SOD in Shandong families with amyotrophic lateral sclerosis |
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| GU Hong-yan,ZHANG Feng-zhen,JIANG Han-ming,SUN Ling-Yun,ZHANG Yuan-ying. Cu,Zn SOD in Shandong families with amyotrophic lateral sclerosis[J]. Journal of Taishan Medical College, 2004, 25(4): 339-340 | |
| Authors: | GU Hong-yan ZHANG Feng-zhen JIANG Han-ming SUN Ling-Yun ZHANG Yuan-ying |
| Affiliation: | Dept.of Biochemistry,Taishan Medical College, Taian 271000,China |
| Abstract: | Objective: To understand the relationship between Cu, Zn .SOD and arnyotrophic lateral sclerosis. Methods:The patients were clinically examined and classified according to the E1 Escorial Criteria, then we obtained blood samples from the patients for Cu, Zn SOD analysis and SOD assay. Amino acid analysis of Cu, Zn SOD were fully automated in in-struments called amino acid analyzers. SOD assay was determined by cytochrome c method Results: Amino acid analysis of Cu, Zn SOD from patients with familial ALS was normal. The activity of Cu, Zn SOD was normal both in familial and sporadic form of ALS compared with normal person,Conclusion;Amyotrophic lateral sclerosis is not related to Cu, Zn SOD.radic form of ALS compared with normal person. Conclusion:Amyotrophic lateral sclerosis is not related to Cu, Zn SOD. |
| Keywords: | Cu, Zn SOD Sporadic amyotrophic lateral sclerosis Familial amyotrophic lateral sclerosis Enzyme activi-ty |
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