RELATIONSHIP BETWEEN GENETIC POLYMORPHISM OF CYP2E1 AND ALDH2, AND POSSIBLE SUSCEPTIBILITY TO ALCOHOLISM期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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RELATIONSHIP BETWEEN GENETIC POLYMORPHISM OF CYP2E1 AND ALDH2, AND POSSIBLE SUSCEPTIBILITY TO ALCOHOLISM

Authors:	IWAHASHI KAZUHIKO; NAKAMURA KAZUHIKO; SUWAKI HIROSHI; MATSUO YOSHINORI; ICHIKAWA YOSHIYUKI

Institution:	^*Departments of Neuropshiatry, Kagwan Medical School Kagawa 761-07, Japan ${dagger}$ Departments of Biochemistry, Kagwan Medical School Kagawa 761-07, Japan

Abstract:	In 45 healthy Japanese volunteers, it was found that personsheterozygous for ALDH2 (ALDH2^1/ALDH2^2), and also either heterozygousor mutant homozygous for CYP2E1 (C₂/C₂ or C₁/C₂ can drink muchmore alcohol, even with (slight) flushing, than persons heterozygousfor ALDH2 (ALDH2^1/ALDH2^2) and normal homozygous for CYP2E1(C₁/C₁)

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