The effects of the GABAergic agonist muscimol upon the relationship between local cerebral blood flow and glucose utilization |
| |
Authors: | Paula AT Kelly James McCulloch |
| |
Institution: | Wellcome Surgical Institute, University of Glasgow, Garscube Estate, Bearsden Road, Glasgow G61 1QH, U.K. |
| |
Abstract: | The relationship between cerebral blood flow and glucose utilization was studied in conscious rats using the 14C]iodoantipyrine and 14C]2-deoxyglucose quantitative autoradiographic techniques respectively. Both blood flow and glucose use decreased in parallel in the 38 areas of the brain analyzed following administration of the GABA agonist muscimol, thus maintaining the relationship observed in control rats. The present study offers no evidence for a direct vasodilatatory action for muscimol in the conscious rat, but points to underlying regional metabolic activity as the primary determinant of cerebral blood flow. |
| |
Keywords: | local cerebral blood flow local cerebral glucose utilization GABA muscimol |
本文献已被 ScienceDirect PubMed 等数据库收录! |