The non immunogenicity of CALLA in leukemic children |
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| Authors: | Y Komada H Yamamoto E Azuma S Tanaka H Kamiya M Sakurai |
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| Affiliation: | Department of Pediatrics, Mie University School of Medicine, Japan. |
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| Abstract: | The sera from 55 children with acute lymphoblastic leukemia (ALL) treated with active immunotherapy were examined for the presence of antibodies against common ALL antigen (CALLA). A solid phase indirect radioimmunometric assay (IRA) was developed which enabled the detection of anti-CALLA antibody in patients' sera, utilizing the ability of affinity-purified CALLA to bind Ricinus communis agglutinin and anti-CALLA antibody simultaneously. Using IRA, anti-CALLA antibody activity could not be detected in a majority of patients. We concluded that the patients did not raise comparable antibodies against CALLA, indicating this antigen is not immunogenic for ALL patients. |
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