Brentuximab vedotin desensitization in a patient with refractory Hodgkin's lymphoma |
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| Authors: | Anubha Arora Vijaya Raj Bhatt Susanne Liewer James O. Armitage R. Gregory Bociek |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, King George's Medical College, Lucknow, India;2. Division of Hematology‐Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA;3. Blood and Marrow Transplant Unit, Department of Pharmacy, Nebraska Medicine, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA |
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| Abstract: | Brentuximab vedotin has emerged as a useful treatment option for relapsed or refractory Hodgkin's lymphoma; however, uncommon cases of anaphylactic reactions may require its permanent discontinuation. We report a 29‐yr‐old woman with refractory Hodgkin's lymphoma, who developed an anaphylactic reaction during the second dose of brentuximab vedotin. A 12‐step desensitization protocol was followed; after premedicating with antihistaminic agents, methylprednisolone and montelukast, a total dose of 156 mg of brentuximab vedotin (1.8 mg/kg) was given as three infusions with increasing rate and concentration. Such desensitization protocol can allow safe administration of brentuximab vedotin and may have a broader applicability in managing hypersensitivity reactions with other monoclonal antibodies. |
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| Keywords: | brentuximab vedotin anaphylaxis desensitization Hodgkin's lymphoma |
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