南宁地区健康成人HbA2和HbA参考范围调查

目的 建立广西南宁地区健康成人血红蛋白(Hb)A2和HbA参考范围.方法 采用Capillarys2毛细管电泳仪检测810例健康成人Hb,以95%参考区间(x±1.96s)建立参考范围.随机选择112例受试对象进行验证试验.结果 男、女HbA2检测结果分别为(2.79±0.24)%和(2.70±0.23)%,组间比较差异有统计学意义(P＜0.01);HbA检测结果分别为(97.14±0.28)%和(97.17±0.39)%,组间比较差异无统计学意义(P＞0.05).不同年龄组HbA2和HbA检测结果差异无统计学意义(P>0.05).HbA2和HbA参考范围分别为2.3%～3.3%、96.4%～97.9%.112例验证标本中,仅1例结果不适于该参考范围.结论 本研究建立的参考范围适用于该地区绝大部分健康成人.

Survey on the reference values of HbA2 and HbA for healthy adults in Nanning

Objective To establish the reference values of hemoglobin(Hb) A2(HbA2) and HbA for healthy adults in Nanning.Methods 810 cases of healthy adults were detected for hemoglobin by Capillarys2 Electrophoresis.Reference values were constructed according to 95% reference range.112 randomly selected subjects were enrolled for verification experiment.Results HbA2 levels in males and females were(2.79±0.24)% and(2.70±0.23)% respectively with statistical difference(P<0.01).HbA levels were(97.14±0.28)% and(97.17±0.39)% in males and females respectively without significant difference(P>0.05).There was no statistical difference of HbA2 and HbA levels between different age groups(P>0.05).Reference values of HbA2 and HbA ranged from 2.3% to 3.3% and from 96.4% to 97.9% respectively.Among all the cases of verification samples,only 1 case was unfit for the reference values.Conclusion Reference values of HbA2 and HbA constructed in the research might be fit for most healthy adults in nanning.