某医院临床分离细菌菌株耐药检测结果与分析

目的 了解该院院内获得病原菌对药物的耐药率和敏感率情况,指导临床用药.方法 收集2010年6月至2011年8月院内患者感染占前5位的病原菌,采用K-B纸片法、ATB药敏试剂盒比色法鉴定对抗菌药物耐药,并进行分析探讨.结果 大肠埃希菌耐药率大于或等于75%的抗菌药物有9种,敏感率大于或等于75%有3种;金黄色葡萄球菌耐药率大于或等于75%的抗菌药物有13种,敏感率50%～74%只有1种;凝固酶阴性葡萄球菌耐药率大于或等于75%的抗菌药物10种,敏感率大于或等于75%只有1种;铜绿假单胞菌耐药率大于或等于75%的抗菌药物有1种,敏感率大于或等于75%有3种;嗜麦芽窄食单胞菌耐药率大于或等于75%的抗菌药物有12种.结论 阿米卡星、美罗培南、亚胺培南对大肠埃希菌保持了较高的抗菌活性;舒普深对凝固酶阴性葡萄球菌保持较高的抗菌活性;阿米卡星、美罗培南、妥布霉素对铜绿假单胞菌保持较高的抗菌活性;复方新诺明对嗜麦芽窄食单胞菌保持较高的抗菌活性,环丙沙星、氨苄西林/舒巴坦对3种细菌耐药率大于或等于75%.

Drug resistance of clinical isolates of bacteria in certain hospital

Objective To investigate the drug resistance and susceptibility of clinical bacterial isolates in certain hospital to supply guidance for clinical medication.Methods The top five pathogenic bacterial strains isolated from patients in the hospital from June,2010 to August,2011 were collected and detected for drug resistance by using K-B paper disk method and ATB susceptibility test kit,utilizing colorimetric method.And the detected results were analyzed.Results For Escherichia coli,more than or equal with 75% were resistant to 9 kinds of antibiotic or sensitive to 3 kinds of antibiotic.For Staphylococcus aureus,more than or equal with 75% were resistant to 13 kinds of antibiotic,and 50%-74% were sensitive to 1 kind of antibiotic.For coagulase negative Staphylococcus,more than or equal with 75% were resistant to 10 kinds of antibiotic or sensitive to 1 kind of antibiotic.For Pseudomonas aeruginosa,more than or equal with 75% were resistant to 1 kind of antibiotic or sensitive to 3 kinds of antibiotic.For Stenotrophomonas maltophilia,more than or equal with 75% were resistant to 12 kinds of antibiotic.Conclusion Escherichia coli strains might be sensitive to Amikacin,Meropenem and Imipenem.Coagulase negative Staphylococcus strains might be sensitive to Sulperazon.Pseudomonas aeruginosa strains might be sensitive to Amikacin,Meropenem and Tobramycin.Stenotrophomonas maltophilia strains might be sensitive to Cotrimoxazole.The drug resistance rate of 3 kinds of bacterium to Ciprofloxacin,Ampicillin/Sulbactam might be more than or equal with 75%.