尿中某些酶测定在丁胺卡那肾毒性监测中的应用

探讨药物致肾损伤早期诊断方法。用酶法测定碱性磷酸酶（ＡＬＰ）。速率法测γ－谷氨酰转肽酶（ＧＧＴ），Ｎ－乙酰－β－Ｄ氨基葡萄糖苷酶（ＮＡＧ）、β－半乳糖苷酶（Ｇａｌ）及肌肝（ＵＣｒ），磺柳酸法测尿蛋白（Ｐｒｏ）。结果：尿酶升高均早于尿蛋白的出现，特别是ＮＡＧ于用药后第３天即有显著升高，Ｇａｌ则在用药后３ｄ内持续升高，尿酶，特别是ＮＡＧ是药物引起肾损伤早期诊断指标。

Application of Urine Enzyme in the Monitoring Nephrotoxicity Induced by Amikacin

To study the diagnosis method of kidney injury indued by amikacin at early stage. ALP was assessed by enzyme method, GGT, NAG, Gal and UCr were observed by routine method, while urinary protein was measured by sulfosalicylic acid method. They were all monitored for 15 days before and after amikacin was given to the subjects. Urine enzyme was increased earlier than the appearance of urinary protein. NAG was increased remarkably on the third day after amikacin was given, while Gal was persistently increased within three days after the drug was given. Urine enzyme, NAG is the index of earlier diagnons is for kidney injury induced by amikacin.