Synthesen von N-Lost-Derivaten, 2. Mitt. Reaktion von N-Bis(2-Chlorethyl)phosphorsäureamid-dichlorid mit 1-Aminopropan-2,3-diol

Synthesis of N-Lost Derivatives, II: Reaction of N,N-bis(2-Chloroethyl)phosphoramidic dichloride with 1-Aminopropane-2,3-diol The reaction between the phosphoramidic dichloride 1 and 1-aminopropane-2,3-diol ( 3 ) affords the five membered ring 9 and not the desired 5-hydroxycyclophosphamide 8 . The structural assignment was based on an independent synthesis of 9 via the benzyl ether 14 .